Research progress in the regulation of allergic rhinitis pathogenesis by the NRF2 pathway.
10.13201/j.issn.2096-7993.2025.08.016
- Author:
Qiqi LI
1
;
Yunfang AN
2
;
Tingting LI
1
;
Jianjun ZHOU
3
;
Weihua WANG
3
Author Information
1. Shanxi Medical University，Taiyuan，030012，China.
2. Department of Otorhinolaryngology Head and Neck Surgery，Second Hospital of Shanxi Medical University.
3. Department of Otorhinolaryngology Head and Neck Surgery，Tongji University Affiliated East Hospital.
- Publication Type:English Abstract
- Keywords:
agonist;
allergic rhinitis;
nuclear factor erythroid 2-related factor 2;
oxidative stress
- MeSH:
NF-E2-Related Factor 2/metabolism*;
Humans;
Rhinitis, Allergic/metabolism*;
Signal Transduction;
Oxidative Stress
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2025;39(8):775-780
- CountryChina
- Language:Chinese
-
Abstract:
In recent years，with the increase in environmental pollution，organisms are exposed to more internal and external oxidative stress factors than ever before.Nuclear factor erythroid 2-related factor 2（nuclear factor erythroid 2-related factor 2，NRF2），as a core transcription factor in response to oxidative stress，maintains cellular redox homeostasis by inducing the expression of various antioxidant factors.The nasal cavity，as the "gateway" of the respiratory tract，is often accompanied by oxidative stress（oxidative stress，OS）damage，leading to the occurrence of allergic rhinitis（allergic rhinitis，AR）.Recent studies have revealed some associations between the NRF2 signaling pathway and the mechanism of AR development.Activation of NRF2 provides a potential protective effect against AR，and some natural NRF2 activators have shown therapeutic potential in clinical experiments.Therefore，this article briefly reviews the relationship between NRF2 and AR，aiming to provide a new therapeutic target and perspective for the treatment of AR.
