Clinical characteristics and prognosis analysis of 108 cases of recurrent nasopharyngeal carcinoma from a single center.
10.13201/j.issn.2096-7993.2025.08.009
- Author:
Qing WANG
1
;
Fusheng LIN
1
;
Ran ZHANG
1
;
Lin GAO
1
;
Xingqian ZHAO
1
;
Jie YANG
1
;
Xiaojiang LI
1
Author Information
1. Department of Head and Neck，Yunnan Cancer Hospital，Kunming，650118，China.
- Publication Type:Journal Article
- Keywords:
nasopharyngeal carcinoma;
prognosi;
recurrence;
survival
- MeSH:
Humans;
Prognosis;
Nasopharyngeal Neoplasms/mortality*;
Nasopharyngeal Carcinoma;
Retrospective Studies;
Neoplasm Recurrence, Local;
Male;
Middle Aged;
Female;
Survival Rate;
Adult;
Risk Factors;
Interleukin-10/blood*;
Aged;
Proportional Hazards Models
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2025;39(8):743-748
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Retrospective analysis of the correlation between clinicopathologic features and related indexes and prognosis in patients with recurrent nasopharyngeal carcinoma. Methods:One hundred and eight nasopharyngeal cancer（NPC） patients with post-treatment recurrence in Yunnan Cancer Hospital from January 2013 to January 2018 were collected, and the survival time was estimated by Kaplan-Meier method, and clinicopathological characteristics were analyzed by log-rank test; risk factors and prognosis were analyzed by Cox proportional risk model for single-factor and multifactorial analysis. A P-value <0.05 was considered statistically significant. Results:The median survival of all patients was 54 months, with a 3-year survival rate of 80.2% and a 5-year survival rate of 39.8%. The 5-year overall survival rate was 50.2% for patients >46 years old and 27.9% for patients ≤46 years old（P<0.05）, a statistically significant difference. Univariate analysis showed that overall survival was associated with age, chemotherapy regimen, EBV early antigen IgA, plasma D-dimer, glycan antigen-125, γ-interferon, α-tumor necrosis factor, IL-10, and IL-4（P<0.05）. Multifactorial analysis revealed that age, chemotherapy regimen, EBV early antigen IgA, plasma D-dimer, glycan antigen-125, and interleukin 10 were independent influences on the prognosis of recurrent nasopharyngeal carcinoma（P<0.05）. Conclusion:Differences in chemotherapy regimens affect the prognosis of recurrent nasopharyngeal carcinoma. Elevated plasma D-dimer, glycan antigen 125, and interleukin 10 levels affect the overall survival of recurrent nasopharyngeal carcinoma, which may be a valid independent prognostic factor, and are expected to provide new biomarkers for nasopharyngeal carcinoma in the clinic.
