Integrated imaging and clinical features of glottic squamous cell carcinoma of the larynx: pathological association and prognosis assessment.
10.13201/j.issn.2096-7993.2025.08.004
- Author:
Yuqiao ZHANG
1
;
Wulin WEN
2
;
Fengxia YANG
2
;
Dongke MA
3
;
Xueliang SHEN
1
;
Ningyu FENG
2
;
Xixi LI
1
;
Zhiling ZENG
1
;
Zhipeng MI
1
;
Xiyuan YAN
1
;
Ruixia MA
2
Author Information
1. The Second Clinical School of Medicine，Ningxia Medical University，Yinchuan，750001，China.
2. Hospital of Otolaryngology，Head and Neck Surgery，the First People's Hospital of Yinchuan.
3. Department of Radiology，General Hospital of Ningxia Medical University.
- Publication Type:Journal Article
- Keywords:
laryngeal neoplasm;
glottic type;
imaging features;
pathological features;
prognosis
- MeSH:
Humans;
Laryngeal Neoplasms/diagnosis*;
Prognosis;
Male;
Female;
Retrospective Studies;
Middle Aged;
Carcinoma, Squamous Cell/diagnosis*;
Magnetic Resonance Imaging;
Glottis/pathology*;
Tomography, X-Ray Computed;
Aged
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2025;39(8):709-716
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical, imaging, and pathological features of glottic squamous cell carcinoma of the larynx and their relationship with prognosis. Methods:A retrospective analysis was conducted on the clinical, imaging, and pathological data of 130 patients with glottic squamous cell carcinoma of the larynx who were treated at the First People's Hospital of Yinchuan and the General Hospital of Ningxia Medical University from January 2018 to March 2023. Imaging examinations （CT and MRI） were used to evaluate the lesion boundary clarity, density, enhancement nature, and enhancement degree. Postoperative pathological examination was used to determine the pathological nature, immunohistochemistry, etc. Statistical methods such as χ² test, Spearman correlation analysis, multivariate logistic regression analysis, and Kaplan-Meier method were used to analyze the data. Results:Among the 130 patients, 127 were male and 3 were female, with an average age of （61.92±9.595） years. There was a correlation between clinical, imaging, and pathological features. Multivariate analysis showed that heterogeneous MRI density （OR=12.414;P=0.019） and squamous cell carcinoma as a subtype were correlated. The initial symptom of non-hoarseness （HR=6.045;P=0.010） and unclear MRI boundary （HR=12.559; P=0.029） were independent risk factors for poor prognosis in patients with glottic squamous cell carcinoma of the larynx. Conclusion:There is a correlation between the clinical, imaging, and pathological features of patients with glottic squamous cell carcinoma of the larynx, and they can affect prognosis. The initial symptom of non-hoarseness and unclear MRI boundary of the tumor are independent risk factors for poor prognosis.
