The role of Staphylococcus aureus in the occurrence and development of chronic rhinosinusitis with nasal polyps.
10.13201/j.issn.2096-7993.2025.07.015
- Author:
Jun NEI
1
;
Yuhuang WU
2
;
Youqin DU
3
Author Information
1. Department of Otolaryngology，Head and Neck Surgery，Yiling Hospital，Yichang，443100，China.
2. College of Science and Technology of China Three Gorges University.
3. College of Basic Medical Science，China Three Gorges University（Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy/Yichang Key Laboratory of Infection and Inflammation）.
- Publication Type:English Abstract
- Keywords:
Staphylococcus aureus;
chronic rhinosinusitis with nasal polyps;
inflammatory response;
microbiome
- MeSH:
Humans;
Sinusitis/microbiology*;
Nasal Polyps/microbiology*;
Staphylococcus aureus;
Chronic Disease;
Rhinitis/microbiology*;
Staphylococcal Infections/microbiology*;
Quorum Sensing;
Biofilms;
Rhinosinusitis
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2025;39(7):679-685
- CountryChina
- Language:Chinese
-
Abstract:
Chronic rhinosinusitis with nasal polyps（CRSwNP） represents a prevalent inflammatory disorder, which is often accompanied by nasal congestion, mucopurulent discharge, olfactory dysfunction, dizziness, and headache. Staphylococcus aureus（SA）, a predominant opportunistic pathogen within the sinonasal microenvironment, has been implicated in modulating the pathogenesis and progression of CRSwNP through multifaceted mechanisms. The physiological activities of SA-dependent quorum-sensing system and biofilm in the nasal microenvironment, including interactions with host, fungi, viruses, and other bacteria, as well as the effects of important superantigens secreted by SA on the microenvironment and immune barrier, are briefly reviewed in this article. These insights provide theoretical foundations for elucidating CRSwNP mechanisms and advancing clinical therapeutic strategies.
