Clinical analysis of 49 cases of malignant lymphoma of the head and neck in children.
10.13201/j.issn.2096-7993.2025.05.015
- Author:
Yanli QU
1
;
Heng ZHAO
1
;
Xuli MA
1
;
Xia LI
1
;
Jing MA
1
Author Information
1. Department of Otorhinolaryngology Head and Neck Surgery，Kunming Children's Hospital，Kunming，650103，China.
- Publication Type:Journal Article
- Keywords:
child;
head and neck;
malignant lymphoma
- MeSH:
Humans;
Male;
Female;
Child;
Head and Neck Neoplasms/therapy*;
Child, Preschool;
Retrospective Studies;
Adolescent;
Lymphoma/therapy*;
Survival Rate;
Hodgkin Disease;
Prognosis;
Infant;
Lymphoma, Non-Hodgkin
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2025;39(5):476-481
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical characteristics of malignant lymphoma of the head and neck in children, and to improve the understanding and diagnosis and treatment of this type of disease by otolaryngologists. Methods:Clinical data of 49 children with malignant lymphoma of the head and neck hospitalized in the Department of Otorhinolaryngology, Head and Neck Surgery of Kunming Children's Hospital from 2013-2021 were retrospectively analyzed and statistically analyzed according to gender, age distribution, duration of the disease, site of onset, type of pathology and survival status. Results:A total of 49 cases of malignant lymphoma of the head and neck in children were collected, of which, 39 were male and 10 female. The minimum age was 3 years, the maximum was 14 years and 4 months, the median age of onset was 7 years, and the largest percentage （51.02%） of children was in the school age（6-12 years）. The duration of the disease ranged from 5 days to 2 years, with a median of 1 month, and the site of the lesion was located in the neck in the majority of cases, 41（83.67%）. The pathologic types of hodgkin lymphoma（HL） were 25 cases（51.02%） and non-hodgkin lymphoma（NHL） were 24 cases（48.98%）, and among hodgkin lymphomas, mixed-cell classical hodgkin lymphoma was the most common, with 9 cases（18.37%）; among non-hodgkin lymphomas,originated from B-cells in 16 cases （32.65%） and from T-cells in 7 cases （14.29%）, with Burkitt's lymphoma being the most numerous of B-cell origin in 13 cases （26.53%）, and T-cell lymphoblastoid lymphoma being the most common of T-cell origin in 4 cases （8.16%）. The follow-up period was from 22 days to 6 years and 10 months, with 3 cases losing, 43 cases surviving, 3 cases dying, with a survival rate of 93 5%, and 3 cases relapsing, with a relapse rate of 6 5%. Conclusion:Children's head and neck malignant lymphoma has its own characteristics in terms of age of onset, gender distribution, site of onset, pathological type and treatment prognosis, which should be comprehensively assessed, diagnosed as early as possible, and multidisciplinary joint treatment actively carried out to propose personalized treatment plans.
