Analysis of the incidence and influencing factors of collateral circulation in high-risk patients with sleep apnea complicated with stroke treated by continuous positive pressure ventilation.
10.13201/j.issn.2096-7993.2025.04.014
- Author:
Linna ZHU
1
;
Yanli ZHOU
1
;
Yang ZHANG
1
;
Yaling LIU
1
Author Information
1. The Fifth Clinical Medical College of He'nan University of Chinese Medicine（Zhengzhou People's Hospital.
- Publication Type:Journal Article
- Keywords:
acute ischemic stroke;
collateral circulation;
continuous positive airway pressure;
obstructive sleep apnea hypopnea syndrome
- MeSH:
Humans;
Collateral Circulation;
Continuous Positive Airway Pressure;
Stroke/physiopathology*;
Sleep Apnea, Obstructive/physiopathology*;
Risk Factors;
Male;
Incidence;
Female;
Middle Aged;
Aged;
Sleep Apnea Syndromes/physiopathology*;
Interleukin-6/blood*
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2025;39(4):368-375
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the incidence of collateral circulation in high-risk patients with sleep apnea and stroke treated by continuous positive airway pressure （CPAP） ventilation and to analyze the influencing factors. Methods:A total of 152 patients diagnosed with obstructive sleep apnea-hypopnea syndrome （OSAHS） combined with acute ischemic stroke （AIS） who were admitted to our hospital from January 2020 to June 2022 were selected for this study. Based on the apnea-hypopnea index （AHI）, the patients were divided into three groups: mild （n=44）, moderate （n=72）, and severe （n=36）. After treatment, the patients were further classified into a group without collateral circulation （n=30） and a group with collateral circulation （n=26）, which included those with moderate collateral circulation （n=69） and good collateral circulation （n=27）. Clinical data across the different groups were compared, and multiple factor analysis was performed to identify factors affecting the occurrence of collateral circulation. Results:The AHI and IL-6 levels in the severe group were significantly higher than those in the mild and moderate groups, while the levels of NO and PO2 were significantly lower in the severe group compared to the mild and moderate groups, with statistically significant differences among the three groups （P<0.05）. After treatment, all groups showed improvement, and the proportion of patients with collateral circulation was 84.09% in the mild group, 81.94% in the moderate group, and 72.22% in the severe group. Significant differences in age, AHI, NIHSS, NO, MoCA, and MMSE scores were observed between the groups with and without collateral circulation （P<0.05）. In the group with collateral circulation, the scores for age, AHI, and NIHSS in the good collateral circulation subgroup were significantly lower than those in the poor collateral circulation and moderate collateral circulation subgroups, while the scores for NO, MoCA, and MMSE were significantly higher in the good collateral circulation subgroup. Multi-factor analysis revealed that age, AHI, and NIHSS were independent risk factors for collateral circulation, whereas NO, MoCA, and MMSE served as protective factors that were negatively correlated with collateral circulation. Classification tree model results indicated that AHI had the greatest influence on the occurrence of collateral circulation among the five influencing factors, demonstrating good predictive capability. Conclusion:Most high-risk patients with sleep apnea and stroke are likely to develop collateral circulation following continuous positive airway pressure ventilation. Factors such as age, AHI, NIHSS, NO, MoCA, and MMSE are important determinants affecting the occurrence of collateral circulation.
