Expression of NFAT5 and IGF1R in nasopharyngeal carcinoma tissues and analysis of clinical characteristics.
10.13201/j.issn.2096-7993.2025.04.008
- Author:
Jie YANG
1
;
Qing WANG
1
;
Fusheng LIN
1
;
Lin GAO
1
;
Ran ZHANG
1
;
Xingqian ZHAO
1
;
Xiaojiang LI
1
Author Information
1. Department of Head and Neck Surgery，Third Affiliated Hospital of Kunming Medical University（Yunnan Cancer Hospital.
- Publication Type:Journal Article
- Keywords:
insulin-like growth factor 1 receptor;
nasopharyngeal carcinoma;
nuclear factor of activated T-cells 5;
prognosis
- MeSH:
Humans;
Nasopharyngeal Carcinoma/pathology*;
Nasopharyngeal Neoplasms/metabolism*;
Prognosis;
Female;
Receptor, IGF Type 1/metabolism*;
Male;
Transcription Factors/metabolism*;
Middle Aged;
Survival Rate;
Adult;
Neoplasm Staging
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2025;39(4):333-343
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of NFAT5 and IGF1R in nasopharyngeal carcinoma tissues and analyze their expression levels in relation to clinical features and prognosis. Methods:From January 1, 2019, to December 31, 2019, 69 cases of nasopharyngeal carcinoma tissues and adjacent non-cancerous tissues were collected from patients treated at Yunnan Cancer Hospital. Immunohistochemistry was employed to detect the expression of NFAT5 and IGF1R in nasopharyngeal carcinoma tissues. The Kaplan-Meier method was used to predict survival time, and the clinicopathological features were evaluated using the log-Rank test. Results:The positive expression rates of NFAT5 and IGF1R in nasopharyngeal carcinoma tissues were 87.0% and 84.5%, respectively. Compared to adjacent normal tissues, the expression levels of NFAT5 and IGF1R in nasopharyngeal carcinoma tissues were significantly increased （P<0.05）. Furthermore, the expression of NFAT5 and IGF1R was positively correlated with T stage, N stage, skull base invasion, and cranial nerve palsy （P<0.05）. The overexpression of NFAT5 and IGF1R significantly affected the survival rate of patients with nasopharyngeal carcinoma and was negatively correlated with prognosis （P<0.05）. Conclusion:In nasopharyngeal carcinoma tissues, overexpression of NFAT5 and IGF1R is observed, which is closely linked to clinical features and patient outcomes. These markers may serve as valuable indicators for predicting the prognosis of nasopharyngeal carcinoma.
