Research progress of aldehyde dehydrogenase type 2 in head and neck malignant tumors.
10.13201/j.issn.2096-7993.2025.03.019
- Author:
Ying LI
1
;
Taowei WU
1
;
Tan CHENG
1
;
Ping HAN
1
Author Information
1. Department of Otolaryngology Head and Neck Surgery，Sun Yat sen Memorial Hospital，Sun Yat sen University，Guangzhou，510220，China.
- Publication Type:English Abstract
- Keywords:
ALDH2;
alcohol;
cancer therapy;
head and neck tumor;
immunity
- MeSH:
Humans;
Head and Neck Neoplasms/enzymology*;
Aldehyde Dehydrogenase, Mitochondrial/genetics*;
Polymorphism, Genetic
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2025;39(3):281-284
- CountryChina
- Language:Chinese
-
Abstract:
Alcohol is a high-risk factor of the head and neck tumor, and acetaldehyde dehydrogenase type 2（ALDH2） is an important alcohol metabolism enzyme in the human body, whose function is to metabolize acetaldehyde into non-toxic acetic acid in the human body. Studies have shown that ALDH2 gene polymorphisms increase the risk of head and neck tumors by affecting enzyme activity to regulate the rate of alcohol metabolism in the body, and high levels of ALDH2 expression are beneficial for enhancing head and neck tumor immunity and improve prognosis. This article aims to review the research progress on the relationship between ALDH2 and the occurrence and treatment of head and neck tumors.
