Prospective randomised controlled observation of tympanic chamber injection of gangliosides in the treatment of refractory sudden deafness.
10.13201/j.issn.2096-7993.2025.03.006
- Author:
Mengyuan WANG
1
;
Qi DONG
2
;
Yuqin XU
2
;
Yaxiu LI
3
;
Jing LIU
1
;
Jie LI
1
;
Wenyan ZHU
4
;
Wandong SHE
1
Author Information
1. Department of Otolaryngology Head and Neck Surgery，Affiliated Drum Tower Hospital of Nanjing University of Chinese Medicine，Nanjing，210008，China.
2. Department of Otolaryngology Head and Neck Surgery，Affiliated Drum Tower Hospital of Nanjing University Medical School.
3. Department of Otolaryngology Head and Neck Surgery，Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University.
4. Department of Otolaryngology，the Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University.
- Publication Type:English Abstract
- Keywords:
ganglioside sodium;
methylprednisolone;
retroauricular injection;
sudden deafness;
tympanic cavity injection
- MeSH:
Humans;
Middle Aged;
Hearing Loss, Sudden/drug therapy*;
Adult;
Prospective Studies;
Young Adult;
Aged;
Adolescent;
Male;
Female;
Injection, Intratympanic;
Gangliosides/administration & dosage*;
Methylprednisolone/therapeutic use*;
Treatment Outcome
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2025;39(3):218-222
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aimed to evaluate the therapeutic effect of intratympanic injection of ganglioside in patients with refractory sudden deafness. Methods:A total of 120 patients with sudden deafness, aged 18-65 years, whose onset was within 11-42 days, failed to respond to conventional treatment, and had an average hearing threshold（500-4 000 Hz）>60 dB were selected. They were prospectively and randomly divided into a control group of 61 cases and an experimental group of 59 cases. The control group was treated according to the recommended protocol of the Chinese Medical Association（postauricular injection of methylprednisolone）, while the experimental group was treated with intratympanic injection of monosialotetrahexosylganglioside sodium+postauricular injection of methylprednisolone. Both groups were simultaneously administered oral ginkgo biloba extract and citicoline tablets. Hearing was re-examined two weeks after the completion of treatment, and the therapeutic effects of the two different treatment methods were compared and analyzed. Results:The effective rate was 29.51% in the control group and 54.24% in the experimental group（P<0.01）. The average hearing threshold improved by 11.57 dB HL in the control group and 22.50 dB HL in the experimental group（P<0.05）. Conclusion:The combination of postauricular injection of methylprednisolone and intratympanic injection of ganglioside is more effective than postauricular injection of methylprednisolone alone in the treatment of refractory sudden deafness. The earlier the treatment, the better the therapeutic effect.
