Preliminary study of gabapentin in the treatment of idiopathic ear fullness.
10.13201/j.issn.2096-7993.2025.03.005
- Author:
Tongxiang DIAO
1
;
Qiuhong HAN
2
;
Xin MA
1
;
Yuanyuan JING
1
;
Lin HAN
1
;
Lisheng YU
1
Author Information
1. Department of Otolaryngology，Head and Neck Surgery，People's Hospital，Peking University，Beijing，100034，China.
2. Department of Otolaryngology，Qinhuangdao Workers' Hospital.
- Publication Type:Journal Article
- Keywords:
central sensitivity syndromes;
gabapentin;
idiopathic aural fullness;
neuropathic pain
- MeSH:
Humans;
Gabapentin/therapeutic use*;
Amines/therapeutic use*;
gamma-Aminobutyric Acid/therapeutic use*;
Female;
Male;
Cyclohexanecarboxylic Acids/therapeutic use*;
Ear Diseases/drug therapy*;
Middle Aged;
Adult;
Aged
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2025;39(3):214-222
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Aural fullness（AF） is one of the common symptoms in ENT outpatient department, the incidence is about 1.4%. Some patients have an unknown etiology and are diagnosed as idiopathic ear congestion. In this paper, the therapeutic effect of gabapentin on some patients with idiopathic ear congestion was studied. Methods:Forty-eight cases of patients with ear distress as the main complaint between January 2024 and September 2024 were examined by questionnaire, specialist physical examination, pure tone audiometry and acoustic impedance. Among them, 19 cases were diagnosed with definite etiology, 29 cases were diagnosed with idiopathic ear congestion, and 7 cases were lost to follow-up in the idiopathic ear congestion group. Twenty-two patients were divided into the administration group（12 cases receiving regular gabapentin treatment for 3-6 weeks） and the control group（10 cases receiving no medication） based on whether they received gabapentin to explore the effect of ear congestion and possible related factors. Results:Among the 12 patients in the medication group, 2 cases of aural fullness disappeared completely, 9 cases had different degrees of relief, and 1 case had no relief Among the 10 patients in the control group, 2 patients' aural fullness disappeared, 1 patient consciously relieved, and the remaining 7 patients had no significant change in ear boredom. According to the Wong-baker Facial expression Scale, the score of ear tightness decreased from 2.83 before medication to 1.51 after medication in the medication group. The remission rate of ear congestion in the medication group was significantly higher than that in the control group（P=0.004）. Conclusion:Gabapentin can be used to treat idiopathic aural fullness, which can reduce the symptoms effectively. This suggests that the occurrence of idiopathic aural fullness may be related to neuralgia and central sensitization.
