The efficacy of vonoprazan fumarate in the treatment of laryngopharyngeal reflux disease evaluated by the Chinese version of the RSS-12 scale.
10.13201/j.issn.2096-7993.2025.01.014
- Author:
Chaorong BIAN
1
;
Peng ZHOU
2
;
Ping SHEN
2
;
Yunpeng ZANG
2
;
Wen LIU
1
Author Information
1. The First Clinical Medical College of Xuzhou Medical University，Xuzhou，221000，China.
2. TheOtolaryngology Department of the Affiliated Hospital of Xuzhou Medical University.
- Publication Type:English Abstract
- Keywords:
chinese version of RSS-12;
laryngopharyngeal reflux disease;
vonoprazan fumarate
- MeSH:
Humans;
Sulfonamides/therapeutic use*;
Male;
Pyrroles/therapeutic use*;
Female;
Laryngopharyngeal Reflux/drug therapy*;
Treatment Outcome;
Middle Aged;
Esomeprazole/therapeutic use*;
Proton Pump Inhibitors/therapeutic use*;
Adult
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2025;39(1):66-76
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the efficacy of vonoprazan fumarate in the treatment of laryngopharyngeal reflux disease（LPRD） evaluated by the Chinese version of the RSS-12 scale. Methods:A total of 100 LPRD patients treated in the otolaryngology-head and neck surgery outpatient clinic of our hospital were randomly divided into two groups（50 cases each）. The observation group was treated with vonoprazan fumarate（20 mg, once daily）, and the control group was treated with esomeprazole enteric-coated capsules（20 mg, twice daily） for 12 weeks. The selected observation indicators in this study included RSI, the Chinese version of RSS-12, and RFS scores before and after treatment. Results:Prior to treatment, there was no statistically significant difference in the Chinese version of RSS-12, RSI, and RFS between the two groups（P>0.05）. After 8 and 12 weeks of antacid treatment, both the Chinese version of RSS-12 and RSI significantly decreased in both group （P<0.05）. The changes in symptoms were particularly noticeable between 0-8 weeks of treatment according to the Chinese version of RSS-12 and RSI. After 12 weeks of treatment, the RFS scores significantly decreased compared to pretreatment levels （P<0.05）. After 12 weeks of antacid treatment, according to the Chinese version of RSS-12, 80% of patients in the observation group showed a good therapeutic response, compared to 64% in the control group; according to RSI, 90% of patients in the observation group showed a good therapeutic response, compared to 84% in the control group. There was no statistically significant difference in the treatment effect between the two groups after 12 weeks of treatment（P>0.05）. Conclusion:Vonoprazan fumarate can significantly improve the symptoms and signs of laryngopharyngeal reflux, and their treatment effect is not inferior to proton pump inhibitors. Compared with RSI, the Chinese version of RSS-12 can serve as a new screening tool for clinical diagnosis of LPRD in China.
