Rescuing lysosomal/autophagic defects via nanoapproach: implications for lysosomal/autophagic defect-related diseases.

Xiaodan HUANG; Yue FANG; Jie SONG; Yuanjing HAO; Yuanyuan CAI; Pengfei WEI; Na ZHANG

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Rescuing lysosomal/autophagic defects via nanoapproach: implications for lysosomal/autophagic defect-related diseases.

Author: Xiaodan HUANG ¹ ; Yue FANG ² ; Jie SONG ¹ ; Yuanjing HAO ¹ ; Yuanyuan CAI ¹ ; Pengfei WEI ³ ; Na ZHANG ⁴
Author Information

1. School of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai 264003, China.
2. Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou Red Cross Hospital, Hangzhou 310003, China.
3. School of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai 264003, China. pfwei@bzmc.edu.cn.
4. School of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai 264003, China. pfwei@bzmc.edu.cn, zhangna20@bzmc.edu.cn.
Publication Type:Review
Keywords: Acidic nanoparticle; Alzheimer’s disease; Autophagy; Dementia; Lysosomal/autophagic disfunction; Lysosome; Transcription factor EB (TFEB)
MeSH: Humans; Lysosomes/physiology*; Autophagy/physiology*; Nanomedicine/methods*; Neurodegenerative Diseases/therapy*; Animals; Nanostructures; Lysosomal Storage Diseases/therapy*
From: Journal of Zhejiang University. Science. B 2025;26(9):813-842
CountryChina
Language:English
Abstract: The dysfunction of the lysosome and autophagy-lysosome system serves as a driving force for neurodegenerative diseases, metabolic disorders, inflammatory conditions, and other related diseases, closely influencing their onset and progression. Therefore, restoring the function of the lysosome or autophagy-lysosome system has become an increasingly crucial therapeutic strategy in disease management. In this review, we will introduce the lysosomal biogenesis, structure, and function, as well as the biological process of the autophagy-lysosome system. Various diseases closely associated with lysosomal/autophagic dysfunction are also reviewed, emphasizing the significance of targeting the function of the lysosome or autophagy-lysosome system in disease treatment. Finally, we focus on engineered nanomaterials that have the capabilities to restore the function of the lysosome or autophagy-lysosome system, and summarize different strategies and methods for achieving this goal. This review aims to elucidate the latest progress in the field of nanomedicine for lysosomal/autophagic defect-related diseases and inspire the development of innovative and clinically valuable nanomedicines.