Effects of Citrus on oxidative stress and lipid metabolism modulation: its potential for improving female reproductive health.
- Author:
Yiyan YANG
1
;
Jue ZHOU
2
Author Information
- Publication Type:Review
- Keywords: Citrus; Female reproductive health; Food; Lipid metabolism; Oxidative stress
- MeSH: Citrus/chemistry*; Oxidative Stress/drug effects*; Female; Humans; Lipid Metabolism/drug effects*; Reproductive Health; Animals; Sirtuin 1/metabolism*; NF-E2-Related Factor 2/metabolism*; Signal Transduction/drug effects*; PPAR alpha/metabolism*
- From: Journal of Zhejiang University. Science. B 2025;26(8):763-777
- CountryChina
- Language:English
- Abstract: Citrus, which has been consumed internationally for a long time, is widely used as a health food. Citrus and its active components exert significant effects on oxidative stress and lipid metabolism, which are closely associated with female reproductive health. Studies suggest that citrus-derived compounds may alleviate oxidative stress by activating signaling pathways such as nuclear factor erythroid 2-related factor 2 (Nrf2) and Sirtuin 1 (SIRT1), and improve lipid metabolism through the activation of pathways such as peroxisome proliferator-activated receptor α (PPARα). This review focuses on the effects of Citrus on oxidative stress and lipid metabolism, aiming to provide new insights for promoting female reproductive health; however, further work is needed to elucidate the mechanisms involved and validate the therapeutic potential of Citrus's bioactive components in clinical settings.
