Small fish making a big difference: beloved star of environmental toxicology research in the current era.

Yang JIANG; Zhen SU; Jing ZHENG; Chih-Hung HSU; Ye CHEN

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Small fish making a big difference: beloved star of environmental toxicology research in the current era.

Author: Yang JIANG ¹ ; Zhen SU ² ; Jing ZHENG ¹ ; Chih-Hung HSU ³ ; Ye CHEN ⁴
Author Information

1. Department of Genetic and Metabolic Disease, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310003, China.
2. College of Life Sciences, Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Zhejiang University, Hangzhou 310058, China.
3. Department of Genetic and Metabolic Disease, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310003, China. yechency@zju.edu.cn, ch_hsu@zju.edu.cn.
4. Department of Genetic and Metabolic Disease, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310003, China. yechency@zju.edu.cn.
Publication Type:Review
Keywords: Environmental toxicant; Environmental toxicology; Zebrafish model
MeSH: Animals; Zebrafish; Ecotoxicology/methods*; Artificial Intelligence; Humans; Models, Animal; Environmental Pollutants/toxicity*
From: Journal of Zhejiang University. Science. B 2025;26(7):613-632
CountryChina
Language:English
Abstract: The zebrafish has emerged as a powerful model organism in life science owing to its remarkable biological characteristics and wide-ranging applications. This review provides a comprehensive overview of the recent advancements in research on zebrafish within the field of environmental toxicology, highlighting specific studies where this species was used to investigate various pollutants to elucidate their impacts and underlying mechanisms. The findings of these studies underscore the significant potential of zebrafish as a model to gain crucial insights into the ecological consequences of environmental contamination and toxicity pathways. By incorporating cutting-edge technologies such as artificial intelligence (AI), high-throughput screening, and omics approaches, the use of zebrafish as a model organism is poised to significantly accelerate toxicological investigations, promote environmental conservation efforts, contribute to safeguarding human health, and advance sustainable development objectives.