Unmet needs of patients with intravascular large B-cell lymphoma: three case reports and a literature review.

Xian LI; Ru LUO; Jiaming XU; Xueli JIN; Weiqin WANG; Xibin XIAO; Wenbin QIAN

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Unmet needs of patients with intravascular large B-cell lymphoma: three case reports and a literature review.

Author: Xian LI ¹ ; Ru LUO ² ; Jiaming XU ³ ; Xueli JIN ¹ ; Weiqin WANG ¹ ; Xibin XIAO ⁴ ; Wenbin QIAN ⁵
Author Information

1. Department of Hematology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
2. Department of Pathology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
3. Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
4. Department of Hematology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China. xiaoxibinzju@zju.edu.cn.
5. Department of Hematology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China. xiaoxibinzju@zju.edu.cn, qianwb@zju.edu.cn.
Publication Type:Review
MeSH: Humans; Antineoplastic Combined Chemotherapy Protocols/therapeutic use*; Lymphoma, Large B-Cell, Diffuse/drug therapy*; Vascular Neoplasms/therapy*
From: Journal of Zhejiang University. Science. B 2025;26(5):493-502
CountryChina
Language:English
Abstract: Intravascular large B-cell lymphoma (IVLBCL), a rare subtype of non-Hodgkin lymphoma, is classified as an independent subtype of extranodal diffuse large B-cell lymphoma (DLBCL) in the 2008 World Health Organization (WHO) Classification (Turner et al., 2010). The 5th edition of the World Health Organization (WHO 2022) classification of hematolymphoid tumors retains this subtype (Alaggio et al., 2022). IVLBCL, which is characterized by neoplastic lymphocyte proliferation within the lumen of small blood vessels, tends to invade organs, such as the nervous system, skin, bone marrow (BM), and lung (D'Angelo et al., 2019; Satoh et al., 2019; Vásquez et al., 2019; Fukami et al., 2020).