Functional redundancy of three mitochondrial Mg2+/Mn2+-dependent protein phosphatases (PPMs) in Toxoplasma gondii.

Kaiyin SHENG; Xueqiu CHEN; Yimin YANG; Jie XIA; Kaiyue SONG; Chaoqun YAO; Yi YANG; Aifang DU; Guangxu MA

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Functional redundancy of three mitochondrial Mg²⁺/Mn²⁺-dependent protein phosphatases (PPMs) in Toxoplasma gondii.

Author: Kaiyin SHENG ¹ ; Xueqiu CHEN ¹ ; Yimin YANG ¹ ; Jie XIA ¹ ; Kaiyue SONG ¹ ; Chaoqun YAO ² ; Yi YANG ¹ ; Aifang DU ³ ; Guangxu MA ⁴
Author Information

1. College of Animal Sciences, Institute of Preventive Veterinary Medicine, Zhejiang University, Hangzhou 310058, China.
2. Department of Biomedical Sciences and One Health Center for Zoonoses and Tropical Infectious Diseases, Ross University School of Veterinary Medicine, Basseterre KN-0101, The Federation of Saint Kitts and Nevis.
3. College of Animal Sciences, Institute of Preventive Veterinary Medicine, Zhejiang University, Hangzhou 310058, China. gxma1@zju.edu.cn, afdu@zju.edu.cn.
4. College of Animal Sciences, Institute of Preventive Veterinary Medicine, Zhejiang University, Hangzhou 310058, China. gxma1@zju.edu.cn.
Publication Type:Journal Article
MeSH: Toxoplasma/enzymology*; Animals; Humans; Toxoplasmosis; Mitochondria/enzymology*; Protozoan Proteins/metabolism*
From: Journal of Zhejiang University. Science. B 2025;26(4):405-408
CountryChina
Language:English
Abstract: Toxoplasma gondii is a single-celled parasite that infects nearly all warm-blooded animals, including humans (Montoya and Liesenfeld, 2004). It occurs worldwide and can persist for a lifetime in mammals. Humans get infected by eating undercooked meat of animals containing the tissue cysts of this parasite. In immune-competent individuals, T. gondii infection usually does not cause significant clinical symptoms, whereas in pregnant or immunocompromised individuals, T. gondii infection (toxoplasmosis) can cause more serious problems like abortion and even death (Dunn et al., 1999; Wang et al., 2017). A combination of pyrimethamine and sulfadiazine is usually used to treat toxoplasmosis, although it is generally inefficient and causes side effects (Alday and Doggett, 2017). Worse still, there is a lack of vaccines to prevent T. gondii infection in humans or animals.