Thirteen serum biochemical indexes and five whole blood coagulation indices in a point-of-care testing analyzer: ideal protocol for evaluating pulmonary and critical care medicine.

Mingtao LIU; Li LIU; Jiaxi CHEN; Zhifeng HUANG; Huiqing ZHU; Shengxuan LIN; Weitian QI; Zhangkai J CHENG; Ning LI; Baoqing SUN

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Thirteen serum biochemical indexes and five whole blood coagulation indices in a point-of-care testing analyzer: ideal protocol for evaluating pulmonary and critical care medicine.

Author: Mingtao LIU ¹ ; Li LIU ¹ ; Jiaxi CHEN ² ; Zhifeng HUANG ¹ ; Huiqing ZHU ¹ ; Shengxuan LIN ³ ; Weitian QI ⁴ ; Zhangkai J CHENG ¹ ; Ning LI ^{5
,

6
,

7} ; Baoqing SUN ^{5
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7}
Author Information

1. Department of Clinical Laboratory, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Laboratory, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510140, China.
2. KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou 511495, China.
3. College of Medical Technology, Guangdong Medical University, Dongguan 523121, China.
4. Second Clinical Medical School, Southern Medical University, Guangzhou 510515, China.
5. Department of Clinical Laboratory, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Laboratory, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510140, China. sunbaoqing@vip.
6. com, lining1971@
7. com.
Publication Type:Journal Article
Keywords: Diagnostic protocol; Five whole blood coagulation indices; Point-of-care testing (POCT); Pulmonary and critical care medicine; Thirteen serum biochemical indexes
MeSH: Humans; Point-of-Care Testing; Critical Care; Blood Coagulation Tests/methods*; Male; Blood Coagulation; Female; Middle Aged; Reproducibility of Results; Prothrombin Time; Aged; Adult; Point-of-Care Systems
From: Journal of Zhejiang University. Science. B 2025;26(2):158-171
CountryChina
Language:English
Abstract: The accurate and timely detection of biochemical coagulation indicators is pivotal in pulmonary and critical care medicine. Despite their reliability, traditional laboratories often lag in terms of rapid diagnosis. Point-of-care testing (POCT) has emerged as a promising alternative, which is awaiting rigorous validation. We assessed 226 samples from patients at the First Affiliated Hospital of Guangzhou Medical University using a Beckman Coulter AU5821 and a PUSHKANG POCT Biochemistry Analyzer MS100. Furthermore, 350 samples were evaluated with a Stago coagulation analyzer STAR MAX and a PUSHKANG POCT Coagulation Analyzer MC100. Metrics included thirteen biochemical indexes, such as albumin, and five coagulation indices, such as prothrombin time. Comparisons were drawn against the PUSHKANG POCT analyzer. Bland-Altman plots (MS100: 0.8206‒0.9995; MC100: 0.8318‒0.9911) evinced significant consistency between methodologies. Spearman correlation pinpointed a potent linear association between conventional devices and the PUSHKANG POCT analyzer, further underscored by a robust correlation coefficient (MS100: 0.713‒0.949; MC100: 0.593‒0.950). The PUSHKANG POCT was validated as a dependable tool for serum and whole blood biochemical and coagulation diagnostics. This emphasizes its prospective clinical efficacy, offering clinicians a swift diagnostic tool and heralding a new era of enhanced patient care outcomes.