Roles of lncRNA in the crosstalk between osteogenesis and angiogenesis in the bone microenvironment.

Shihua ZHANG; Jianmin GUO; Yuting HE; Zhi'ang SU; Yao FENG; Lan ZHANG; Zou JUN; Xiquan WENG; Yu YUAN

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Roles of lncRNA in the crosstalk between osteogenesis and angiogenesis in the bone microenvironment.

Author: Shihua ZHANG ¹ ; Jianmin GUO ² ; Yuting HE ¹ ; Zhi'ang SU ¹ ; Yao FENG ¹ ; Lan ZHANG ³ ; Zou JUN ⁴ ; Xiquan WENG ^{5
,

6} ; Yu YUAN ^{5
,

7}
Author Information

1. School of Exercise and Health, Guangzhou Sport University, Guangzhou 510500, China.
2. School of Life Sciences, South University of Science and Technology, Shenzhen 518055, China.
3. College of Sports and Health, Shandong Sport University, Jinan 250102, China.
4. School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China.
5. School of Exercise and Health, Guangzhou Sport University, Guangzhou 510500, China. yuanyumail@
6. com, wengxq@gzsport.edu.cn.
7. com.
Publication Type:Review
Keywords: Bone angiogenesis; Bone microenvironment; Long noncoding RNA (lncRNA); Osteogenesis; Osteoporosis
MeSH: RNA, Long Noncoding/physiology*; Osteogenesis/physiology*; Humans; Neovascularization, Physiologic/genetics*; Bone and Bones/metabolism*; Animals; Mesenchymal Stem Cells; Signal Transduction; Osteoblasts; Osteoclasts; Angiogenesis
From: Journal of Zhejiang University. Science. B 2025;26(2):107-123
CountryChina
Language:English
Abstract: Bone is a highly calcified and vascularized tissue. The vascular system plays a vital role in supporting bone growth and repair, such as the provision of nutrients, growth factors, and metabolic waste transfer. Moreover, the additional functions of the bone vasculature, such as the secretion of various factors and the regulation of bone-related signaling pathways, are essential for maintaining bone health. In the bone microenvironment, bone tissue cells play a critical role in regulating angiogenesis, including osteoblasts, bone marrow mesenchymal stem cells (BMSCs), and osteoclasts. Osteogenesis and bone angiogenesis are closely linked. The decrease in osteogenesis and bone angiogenesis caused by aging leads to osteoporosis. Long noncoding RNAs (lncRNAs) are involved in various physiological processes, including osteogenesis and angiogenesis. Recent studies have shown that lncRNAs could mediate the crosstalk between angiogenesis and osteogenesis. However, the mechanism by which lncRNAs regulate angiogenesis‒osteogenesis crosstalk remains unclear. In this review, we describe in detail the ways in which lncRNAs regulate the crosstalk between osteogenesis and angiogenesis to promote bone health, aiming to provide new directions for the study of the mechanism by which lncRNAs regulate bone metabolism.