Mechanisms of spinal microglia and astrocytes in exercise-induced analgesia.
10.11817/j.issn.1672-7347.2025.250268
- Author:
Shuang HU
1
,
2
,
3
;
Haojun YOU
1
;
Jing LEI
1
,
3
,
4
Author Information
1. Center for Translational Medicine on Sensory-Motor diseases, Yan'an University, Yan'an
2. hushuang_47@
3. com.
4. jinglei_2000@
- Publication Type:English Abstract
- Keywords:
exercise patterns;
exercise-induced analgesia;
glial cells;
inflammatory signaling pathways;
pathological pain
- MeSH:
Humans;
Microglia/metabolism*;
Astrocytes/metabolism*;
Exercise/physiology*;
Signal Transduction;
Analgesia/methods*;
Spinal Cord/cytology*;
Exercise Therapy;
Pain Management/methods*;
Animals;
Brain-Derived Neurotrophic Factor/metabolism*
- From:
Journal of Central South University(Medical Sciences)
2025;50(8):1455-1464
- CountryChina
- Language:Chinese
-
Abstract:
Exercise-induced analgesia (EIA) refers to the elevation of pain thresholds and reduction in sensitivity to noxious stimuli achieved through exercise training. As a non-pharmacological treatment strategy, exercise therapy has demonstrated positive effects on both acute and chronic pain. Increasing evidence indicates that modulation of glial cell activity is an important mechanism underlying analgesia. Spinal glial cells contribute to the development and maintenance of pathological pain by promoting pain signal transmission through inflammatory responses and synaptic remodeling. Exercise can differentially regulate microglia and astrocyte activity, inhibiting multiple inflammatory signaling pathways, such as P2X4/P2X7 purinergic receptors, brain-derived neurotrophic factor (BDNF)/phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR), interleukin (IL)-6/Janus kinase (JAK) 2/signal transducer and activator of transcription 3 (STAT3), p38-mitogen-activated protein kinases (MAPK), and Toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB), thereby reducing the release of pro-inflammatory cytokines, decreasing inflammatory and nociceptive hypersensitivity, and alleviating pathological pain. This review also summarized the effects of different exercise intensities, durations, and frequencies on glial cell responses in order to provide a theoretical foundation for optimizing exercise-based interventions for pathological pain conditions.
