Risks, mechanisms, and prevention strategies for cerebrovascular diseases in lunar astronauts under deep.
10.11817/j.issn.1672-7347.2025.250533
- Author:
Lei TANG
1
,
2
;
Qiaoling TANG
1
;
Ye LI
1
;
Li WANG
1
;
Feng ZHANG
1
;
Xiangbin ZHANG
1
;
Ran LIU
1
;
Le ZHANG
1
,
3
Author Information
1. Department of Neurology, Xiangya Hospital, Central South University, Changsha
2. 238102003@csu.edu.cn.
3. zlzdzlzd@csu.edu.cn.
- Publication Type:English Abstract
- Keywords:
cerebrovascular diseases;
deep space exploration;
lunar astronauts;
microgravity;
space medicine
- MeSH:
Humans;
Astronauts;
Cerebrovascular Disorders/etiology*;
Space Flight;
Weightlessness/adverse effects*;
Risk Factors;
Moon
- From:
Journal of Central South University(Medical Sciences)
2025;50(8):1337-1345
- CountryChina
- Language:Chinese
-
Abstract:
As human deep space exploration enters a practical phase, ensuring astronaut health and safety has become a critical determinant of mission success. The cerebrovascular system, essential for maintaining brain function, is highly sensitive to environmental changes. Cerebrovascular diseases represent one of the characteristic adverse effects of deep space conditions such as microgravity and high-energy radiation, and have emerged as a frontier challenge in space medicine. Based on experiences from manned space missions, major research challenges persist, particularly the lack of experimental data specific to the lunar environment and the unclear threshold for low-dose radiation-induced injury. Elucidating the mechanisms and multifactorial interactions by which deep space environments impact cerebrovascular structure and function, and summarizing the key risk factors, pathological processes, and recent advances in monitoring and early-warning technologies for cerebrovascular diseases in lunar astronauts, and of crucial importance. A comprehensive understanding of the interplay between deep space environmental stressors and cerebrovascular injury, as well as the development of personalized prevention and intervention strategies, will provide both theoretical and practical foundations for safeguarding cerebrovascular health in future Chinese deep space missions, while promoting progress in related biomedical research, technological innovation, and international collaboration.
