Application advances of fractional flow reserve in endovascular treatment of lower-extremity arterial disease.
10.11817/j.issn.1672-7347.2025.250239
- Author:
Lei ZHANG
1
,
2
;
Jian QIU
1
;
Dingxiao LIU
1
;
Pengcheng GUO
1
;
Dexiang XIA
1
;
Chang SHU
1
;
Xin LI
1
,
3
Author Information
1. Department of Vascular Surgery, Second Xiangya Hospital, Central South University, Changsha
2. zhanglei2022@csu.edu.cn.
3. lixin1981@csu.edu.cn.
- Publication Type:English Abstract
- Keywords:
endovascular therapy;
fractional flow reserve;
functional assessment;
lower-extremity arterial disease;
precision medicine
- MeSH:
Humans;
Lower Extremity/blood supply*;
Peripheral Arterial Disease/diagnosis*;
Fractional Flow Reserve, Myocardial;
Endovascular Procedures/methods*;
Intermittent Claudication/physiopathology*
- From:
Journal of Central South University(Medical Sciences)
2025;50(7):1255-1262
- CountryChina
- Language:Chinese
-
Abstract:
Fractional flow reserve (FFR), an established modality for functionally assessing coronary artery disease, is increasingly applied to diagnose and manage lower extremity arterial disease. By incorporating functional parameters, FFR enhances revascularization precision by quantifying the hemodynamic impact of stenotic lesions, thereby overcoming limitations of conventional imaging. Key clinical applications in lower extremity disease include functional assessment in moderate intermittent claudication, post-vascular preparation strategy optimization, and predicting revascularization outcomes and complications. Advances in pressure wire and microcatheter systems, alongside non-invasive imaging-derived FFR techniques, are improving its feasibility and applicability. However, widespread adoption is challenged by the complex anatomy of the lower extremity arterial system, frequent severe calcification and diffuse disease, and a current lack of standardized FFR cutoff values. Promoting the standardized use of FFR is crucial for shifting the clinical management paradigm from anatomy-based repair toward functional reconstruction.
