Predictive value of ultrasound-derived quantitative indicators of umbilical cord hypercoiling and hemodynamic parameters for adverse pregnancy outcomes.
10.11817/j.issn.1672-7347.2025.250160
- Author:
Xiaotan TAN
1
,
2
;
Qichang ZHOU
3
;
Hongxia YUAN
4
;
Da HOU
1
,
5
;
Yunfang ZHU
4
;
Ruji YAO
4
Author Information
1. Health Management Center, Changsha Hospital for Maternal and Child Health Care, Changsha
2. 28628671@qq.com.
3. Department of Ultrasound Medicine, Second Xiangya Hospital, Central South University, Changsha
4. Department of Ultrasound Medicine, Changsha Hospital for Maternal and Child Health Care, Changsha 410007, China.
5. 23176555@qq.com.
- Publication Type:Journal Article
- Keywords:
adverse pregnancy outcomes;
cerebroplacental ratio;
excessive umbilical cord coiling;
pitch value;
umbilical coiling index
- MeSH:
Humans;
Female;
Pregnancy;
Pregnancy Outcome;
Adult;
Ultrasonography, Prenatal/methods*;
Umbilical Cord/diagnostic imaging*;
Hemodynamics;
Predictive Value of Tests;
Infant, Newborn;
ROC Curve
- From:
Journal of Central South University(Medical Sciences)
2025;50(7):1179-1187
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:The diagnostic value of ultrasonographic quantitative indicators of umbilical cord coiling, such as the umbilical coiling index (UCI) and pitch value, in identifying hypercoiling and predicting adverse pregnancy outcomes remains controversial. This study aims to evaluate the predictive value of UCI, pitch value, and the cerebroplacental ratio in pregnancies complicated by umbilical cord hypercoiling.
METHODS:Pregnant women with densely coiled umbilical cords identified by routine obstetric ultrasound at Changsha Maternal and Child Health Hospital between November 2022 and November 2024 were enrolled. Complete clinical data, including UCI, pitch value, and cerebroplacental ratio (CPR), were collected. Pregnancy outcome scores were calculated, and newborns were categorized into the normal outcome group (n=177) and adverse outcome group (n=85), with the latter further subdivided into mild (n=51), moderate (n=19), and severe (n=15) subgroups. Differences in baseline data, UCI, pitch value, and incidence of CRP<1 were compared between groups and among subgroups. Correlations between UCI, pitch value, and adverse pregnancy outcomes were analyzed. Receiver operating characteristic (ROC) curve were used to assess the predictive performance of UCI, pitch value, CPR<1, and their combinations.
RESULTS:Compared with the normal outcome group, the adverse outcome group had higher age, parity, parity, incidence of CPR<1, and UCI, while gestational age at delivery and pitch values were lower (all P<0.05). The incidence of obesity, gestational diabetes mellitus, and hypertensive disorders of pregnancy did not differ significantly between the 2 groups (all P>0.05). The normal outcome group showed lower UCI and higher pitch values than all 3 adverse outcome subgroups (all P<0.05), while differences among the 3 adverse subgroups were not significant (all P>0.05). UCI was positively correlated with adverse pregnancy outcomes (rs=0.350, P<0.05), whereas pitch value was negatively correlated (rs=-0.286, P<0.05). ROC curve analysis showed that the area under the curve (AUC) values for predicting adverse outcomes were 0.837 for UCI, 0.886 for pitch value, and 0.610 for CPR<1, with sensitivities of 77.6%, 82.4%, and 27.1% and specificities of 78.5%, 83.6%, and 94.9%, respectively. The combined UCI+CPR<1 and pitch value+CPR<1 models yielded AUCs of 0.841 and 0.886, with sensitivities of 78.8% and 81.2% and specificities of 78.5% and 84.2%, respectively. No significant differences were found between the AUCs of UCI and pitch value (P>0.05), but both outperformed CPR<1 alone (both P<0.001). The combined models showed no significant improvement over UCI or pitch value alone (both P>0.05), though both were superior to CPR<1 alone (both P<0.001).
CONCLUSIONS:Most umbilical cord hypercoiling cases had favorable outcomes, with UCI, pitch value, CPR<1 and their combinations demonstrating significant predictive value for adverse pregnancy outcomes.
