Therapeutic effects of natural products on animal models of chronic obstructive pulmonary disease.
10.11817/j.issn.1672-7347.2025.240124
- Author:
Xinru FEI
1
,
2
;
Guixian YANG
3
;
Junnan LIU
4
;
Tong LIU
4
;
Wei GAO
4
;
Dongkai ZHAO
5
Author Information
1. School of Rehabilitation Medicine, Changchun University of Chinese Medicine, Changchun
2. 2754373030@qq.com.
3. Department of Training and Education, Third Affiliated Hospital, Changchun University of Chinese Medicine, Changchun
4. Department of Pulmonary Diseases, Third Affiliated Hospital, Changchun University of Chinese Medicine, Changchun 130117, China.
5. Department of Pulmonary Diseases, Third Affiliated Hospital, Changchun University of Chinese Medicine, Changchun 130117, China. 2499515055@qq.com.
- Publication Type:English Abstract
- Keywords:
animal models;
chronic obstructive pulmonary disease;
modeling methods;
natural products;
therapeutic effects
- MeSH:
Pulmonary Disease, Chronic Obstructive/etiology*;
Animals;
Disease Models, Animal;
Biological Products/pharmacology*;
Humans;
NF-kappa B/metabolism*;
Flavonoids/pharmacology*;
Signal Transduction/drug effects*;
Anti-Inflammatory Agents/pharmacology*;
Heme Oxygenase-1/metabolism*;
Terpenes/pharmacology*;
Antioxidants/pharmacology*;
NF-E2-Related Factor 2/metabolism*;
Smoke/adverse effects*;
Phenols/therapeutic use*
- From:
Journal of Central South University(Medical Sciences)
2025;50(6):1067-1079
- CountryChina
- Language:Chinese
-
Abstract:
Chronic obstructive pulmonary disease (COPD) currently lacks effective treatments to halt disease progression, making the search for preventive and therapeutic drugs a pressing issue. Natural products, with their accessibility, affordability, and low toxicity, offer promising avenues. Investigating the pharmacological effects and related signaling mechanisms of active components from natural products on COPD animal models induced by various triggers has become an important focus. In animal models induced by cigarette smoke, cigarette smoke combined with lipopolysaccharide (LPS), air pollution, elastase, bacterial or viral infections, the active compounds of natural products, such as flavonoids, terpenoids, and phenolics, can exert anti-inflammatory, antioxidant, mucus-regulating, and airway remodeling-inhibiting effects through key signaling pathways including nuclear factor-erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1), nuclear factor-kappa B (NF-κB), and mitogen-activated protein kinase (MAPK). These findings not only provide a theoretical basis for the clinical diagnosis and treatment of COPD but also point to new directions for future scientific research.
