Research progress on bioactive peptides in the treatment of oral diseases.
10.11817/j.issn.1672-7347.2025.240585
- Author:
Weiman HUANG
1
,
2
;
Yujing WANG
3
;
Xidi WANG
3
;
Kun LI
4
Author Information
1. Department of Maxillofacial Surgery, Xiangya Hospital of Stomatology, Central South University, Changsha 410013, China. hwm990520@
2. com.
3. Department of Maxillofacial Surgery, Xiangya Hospital of Stomatology, Central South University, Changsha 410013, China.
4. Department of Maxillofacial Surgery, Xiangya Hospital of Stomatology, Central South University, Changsha 410013, China. likun0116@csu.edu.cn.
- Publication Type:Review
- Keywords:
bioactive peptides;
biological properties;
clinical translation;
drug degradation;
oral administration;
oral diseases
- MeSH:
Humans;
Peptides/administration & dosage*;
Mouth Diseases/drug therapy*;
Administration, Oral
- From:
Journal of Central South University(Medical Sciences)
2025;50(5):907-912
- CountryChina
- Language:English
-
Abstract:
Peptide-based drugs possess several advantages, including high specificity, low immunogenicity, minimal accumulation, and fewer drug-drug interactions, making them a novel and efficient therapeutic class for various diseases. In recent years, peptide-based drugs have shown great potential and broad application prospects in the treatment of oral infectious diseases, tissue injury and repair, tumors, and complex oral mucosal disorders, acting either through direct mechanisms or indirect modulation. Oral administration remains the preferred route due to its non-invasive, painless nature and ease of management; however, gastrointestinal pH can inactivate or even degrade peptide drugs. In the treatment of oral diseases, local administration is commonly employed, avoiding gastrointestinal degradation and first-pass metabolism. Nevertheless, limitations in current theoretical research and the high cost of peptide synthesis hinder their clinical application. Future efforts should focus on advancing related studies to promote the practical application of peptide-based drugs in the field of oral medicine.
