Impact of muscle strength decline and exercise intervention on multimorbidity of chronic diseases in older adults.
10.11817/j.issn.1672-7347.2025.240509
- Author:
Yajing ZHAO
1
,
2
;
Peizhen ZHANG
3
Author Information
1. School of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, China. anyaandayna@
2. com.
3. School of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, China. zhpzh17@hotmail.com.
- Publication Type:Review
- Keywords:
exercise intervention;
multimorbidity of chronic diseases;
muscle strength;
older adults;
sports medicine
- MeSH:
Humans;
Aged;
Chronic Disease/prevention & control*;
Muscle Strength/physiology*;
Multimorbidity;
Quality of Life;
Resistance Training;
Exercise Therapy;
Exercise;
Sarcopenia
- From:
Journal of Central South University(Medical Sciences)
2025;50(5):897-906
- CountryChina
- Language:English
-
Abstract:
Multimorbidity of chronic diseases is one of the most common health issues among older adults, and the resulting demand for long-term medical care and management imposes a considerable burden on healthcare systems. Muscle strength, a core indicator of overall health status, is closely associated with the risk of developing multimorbidity of chronic diseases in older adults. Decline in muscle strength not only increases the risk of multimorbidity of chronic diseases but also interacts with it to exacerbate disease burden. In older adults with existing multimorbidity of chronic diseases, muscle strength decline can impair physical function and quality of life, leading to a vicious cycle of disease progression and physical disability. Strength training can help prevent multimorbidity, with potential mechanisms including the promotion of anti-inflammatory effects and enhancement of mitochondrial energy metabolism. This review summarizes the impact of muscle strength decline on multimorbidity of chronic diseases in older adults and the effectiveness and potential mechanisms of exercise interventions, providing evidence to delay muscle strength decline, prevent the occurrence and progression of multimorbidity of chronic diseases, and improve quality of life in older adults.
