Mechanism of post cardiac arrest syndrome based on animal models of cardiac arrest.

Halidan ABUDU; Yiping WANG; Kang HE; Ziquan LIU; Liqiong GUO; Jinrui DONG; Ailijiang KADEER; Guowu XU; Yanqing LIU; Xiangyan MENG; Jinxia CAI; Yongmao LI; Haojun FAN

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Mechanism of post cardiac arrest syndrome based on animal models of cardiac arrest.

Author: Halidan ABUDU ^{1
,

2
,

3} ; Yiping WANG ¹ ; Kang HE ⁴ ; Ziquan LIU ¹ ; Liqiong GUO ¹ ; Jinrui DONG ¹ ; Ailijiang KADEER ⁵ ; Guowu XU ⁶ ; Yanqing LIU ¹ ; Xiangyan MENG ¹ ; Jinxia CAI ¹ ; Yongmao LI ¹ ; Haojun FAN ^{1
,

3
,

7}
Author Information

1. Scool of Disaster and Emergency Medicine, Tianjin University, Tianjin
2. halida_abudou@
3. com.
4. Bioengineering College of Chongqing University, Chongqing
5. Department of Medical Oncology, First Affiliated Hospital of Bengbu Medical University, Bengbu
6. Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China.
7. haojunfan86@
Publication Type:Review
Keywords: animal model; cardiac arrest; modeling method; pathophysiology; post cardiac arrest syndrome
MeSH: Animals; Disease Models, Animal; Post-Cardiac Arrest Syndrome/physiopathology*; Heart Arrest/physiopathology*; Humans; Ventricular Fibrillation/complications*
From: Journal of Central South University(Medical Sciences) 2025;50(5):731-746
CountryChina
Language:English
Abstract: Cardiac arrest (CA) is a critical condition in the field of cardiovascular medicine. Despite successful resuscitation, patients continue to have a high mortality rate, largely due to post CA syndrome (PCAS). However, the injury and pathophysiological mechanisms underlying PCAS remain unclear. Experimental animal models are valuable tools for exploring the etiology, pathogenesis, and potential interventions for CA and PCAS. Current CA animal models include electrical induction of ventricular fibrillation (VF), myocardial infarction, high potassium, asphyxia, and hemorrhagic shock. Although these models do not fully replicate the complexity of clinical CA, the mechanistic insights they provide remain highly relevant, including post-CA brain injury (PCABI), post-CA myocardial dysfunction (PAMD), systemic ischaemia/reperfusion injury (IRI), and the persistent precipitating pathology. Summarizing the methods of establishing CA models, the challenges encountered in the modeling process, and the mechanisms of PCAS can provide a foundation for developing standardized CA modeling protocols.