Role and mechanisms of interneurons in chronic pain and pain-induced cognitive impairment.
10.11817/j.issn.1672-7347.2025.240402
- Author:
Qi WANG
1
;
Guangfen ZHANG
2
;
Bo WANG
3
Author Information
1. Department of Anesthesiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China. itsritazz@sina.com.
2. Department of Anesthesiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China.
3. Department of Anesthesiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China. wangb1688@sina.com.
- Publication Type:Review
- Keywords:
cognitive impairment;
interneurons;
pain;
pathogenesis;
signal transmission
- MeSH:
Interneurons/physiology*;
Humans;
Chronic Pain/complications*;
Cognitive Dysfunction/physiopathology*;
Cognition Disorders/physiopathology*;
Animals
- From:
Journal of Central South University(Medical Sciences)
2025;50(4):625-630
- CountryChina
- Language:English
-
Abstract:
Chronic pain, a prevalent chronic disease, frequently manifests not only in physical symptoms but also in cognitive impairment, which seriously affects patients' quality of life. Interneurons are multipolar neurons, most of which are inhibitory, serving as crucial connectors within neural networks. They play key roles in signal transmission and fine-tuning of neural activity. In recent years, growing evidence has shown that interneurons are involved in the development of chronic pain and its associated cognitive dysfunction. Investigating the relationship between interneuron dysfunction and chronic pain-related cognitive impairment is of great significance, offering new potential targets and insights for the development of novel therapeutic approaches.
