Research progress in the role of ultraviolet in the pathogenesis of rosacea.
10.11817/j.issn.1672-7347.2025.240075
- Author:
Yuming XIE
1
;
Yue HU
2
;
Junke HUANG
2
;
Juan LIU
2
;
Qing ZHANG
3
Author Information
1. Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha 410011, China. xieyuming@csu.edu.cn.
2. Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
3. Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha 410011, China. zhangqing3135@csu.edu.cn.
- Publication Type:Review
- Keywords:
LL-37;
matrix metalloproteinase;
reactive oxygen species;
rosacea;
ultraviolet;
vascular endothelial growth factor
- MeSH:
Humans;
Rosacea/metabolism*;
Ultraviolet Rays/adverse effects*;
Cathelicidins;
Reactive Oxygen Species/metabolism*;
Antimicrobial Cationic Peptides/metabolism*;
Matrix Metalloproteinases/metabolism*;
Vascular Endothelial Growth Factor A/metabolism*;
Skin/metabolism*
- From:
Journal of Central South University(Medical Sciences)
2025;50(3):396-401
- CountryChina
- Language:English
-
Abstract:
Rosacea is a common chronic inflammatory skin disease that predominantly affects the central face. It can impair appearance and cause various discomforts, thus negatively impacting patients' physical and mental well-being as well as their quality of life. Its pathophysiological mechanisms involve multiple factors. Studies have confirmed that ultraviolet radiation plays a significant role in the pathogenesis of rosacea, affecting skin tissues, cells, DNA, and proteins, and inducing oxidative damage. Ultraviolet can lead to the occurrence and development of rosacea by up-regulating the expression of LL-37, matrix metalloproteinase, vascular endothelial growth factor, and reactive oxygen species, and influence their interactions, thereby triggering inflammatory responses, altering the dermal matrix, and promoting capillary dilation and neovascularization, which contribute to the onset and progression of rosacea. Exploring the role of ultraviolet in the pathogenesis of rosacea can provide new strategies for protection and treatment, and enhance awareness of ultraviolet protection among patients with rosacea.
