Characteristics and differential diagnosis of common verrucous proliferative skin diseases under dermoscopy and reflectance confocal microscopy.
10.11817/j.issn.1672-7347.2025.240708
- Author:
Lu ZHOU
1
,
2
;
Yule FU
3
,
4
;
Jian HUANG
1
;
Zhen TANG
1
;
Jianyun LU
1
;
Lina TAN
1
;
Dan WANG
1
;
Jinrong ZENG
1
;
Jia WANG
5
;
Lihua GAO
1
,
6
Author Information
1. Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha
2. 290991732@qq.com.
3. Xiangya School of Medicine, Central South University, Changsha 410013, China. fu1375415081@
4. com.
5. Xiangya School of Medicine, Central South University, Changsha 410013, China.
6. 49516596@qq.com.
- Publication Type:Journal Article
- Keywords:
dermoscopy;
nevus sebaceous;
reflectance confocal microscopy;
seborrheic keratosis;
verruca plana;
verruca vulgaris;
verrucous epidermal nevus;
verrucous proliferation
- MeSH:
Humans;
Dermoscopy/methods*;
Diagnosis, Differential;
Microscopy, Confocal/methods*;
Male;
Female;
Adult;
Middle Aged;
Adolescent;
Keratosis, Seborrheic/pathology*;
Young Adult;
Warts/diagnosis*;
Child;
Aged;
Skin Diseases/pathology*;
Nevus, Sebaceous of Jadassohn/diagnosis*;
Skin Neoplasms/diagnosis*;
Child, Preschool
- From:
Journal of Central South University(Medical Sciences)
2025;50(3):358-365
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:Verrucous epidermal nevus (VEN), seborrheic keratosis (SK), verruca plana (VP), verruca vulgaris (VV), and nevus sebaceous (NS) are common verrucous proliferative skin diseases with similar clinical appearances, often posing diagnostic challenges. Dermoscopy and reflectance confocal microscopy (RCM) can aid in their differentiation, yet their specific features under these tools have not been systematically described. This study aims to summarize and analyze the dermoscopic and RCM features of VEN, SK, VP, VV, and NS.
METHODS:A total of 121 patients with histopathologically confirmed verrucous proliferative skin diseases were enrolled. Dermoscopy and RCM imaging was used to observe and analyze the microscopic features of these conditions.
RESULTS:Under dermoscopy, the 5 diseases displayed distinct characteristics: VEN typically showed gyriform structures; SK was characterized by gyriform structures, comedo-like openings, and milia-like cysts; VP and VV featured dotted vessels and frogspawn-like structures; NS presented as brownish-yellow globules. RCM revealed shared features such as hyperkeratosis and acanthosis across all 5 diseases. Specific features included gyriform structures and elongated rete ridges in VEN; pseudocysts and gyriform structures in SK; evenly distributed ring-like structures in VP; vacuolated cells and papillomatous proliferation in VV; and frogspawn-like structures in NS.
CONCLUSIONS:These 5 verrucous proliferative skin conditions exhibit distinguishable features under both dermoscopy and RCM. The combination of these 2 noninvasive imaging modalities holds significant clinical value for the differential diagnosis of verrucous proliferative skin diseases.
