Non-bioartificial liver support system in the treatment of pediatric acute liver failure.
10.11817/j.issn.1672-7347.2025.240184
- Author:
Na TIAN
1
,
2
;
Qiang SUN
3
Author Information
1. Blood Purification Center, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China. putini@
2. com.
3. Blood Purification Center, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China. sunqiang@bch.com.cn.
- Publication Type:Review
- Keywords:
acute liver failure;
artificial liver;
blood purification;
non-bioartificial;
pediatrics
- MeSH:
Humans;
Liver Failure, Acute/therapy*;
Liver, Artificial;
Plasma Exchange/methods*;
Child
- From:
Journal of Central South University(Medical Sciences)
2025;50(2):266-274
- CountryChina
- Language:English
-
Abstract:
Pediatric acute liver failure (PALF) is a severe and rare clinical syndrome characterized by rapid progression and high mortality. Current main treatment strategies include medical therapy, artificial liver support, and liver transplantation. Given the limited efficacy of medical treatment and the challenges of liver transplantation, such as donor scarcity and high costs, the non-biological artificial liver (NBAL) support system has become a widely used and effective alternative in clinical practice. It provides critical time for liver function recovery or as a bridging therapy to transplantation. Common NBAL modalities include plasma exchange (PE), plasma adsorption (PA), albumin dialysis (AD), and various combination therapies. Therapeutic PE removes toxins by replacing plasma and is suitable as adjuvant therapy in liver failure; high-volume PE is used in acute liver failure but is costly. PA and double plasma molecular adsorption systems remove specific toxins while reducing plasma consumption. AD systems eliminate macromolecular toxins through different mechanisms. Hybrid blood purification therapies combine multiple modes to enhance solute clearance efficiency. Elucidating the clinical characteristics and applications of various NBAL techniques in pediatric acute liver failure may provide valuable guidance for the use of NBAL support systems in pediatric clinical practice.
