T cell characteristics in individuals with different immune responses after hepatitis B vaccination.
10.11817/j.issn.1672-7347.2024.240172
- Author:
Zhiyong HAN
1
;
Dan WANG
2
;
Xiaoyan HE
2
;
Qiang XIA
3
,
4
Author Information
1. Department of Immunology and Pathogen Biology, Zhuhai Campus of Zunyi Medical University, Zhuhai Guangdong 519041, China. 714429210@qq.com.
2. Department of Immunology and Pathogen Biology, Zhuhai Campus of Zunyi Medical University, Zhuhai Guangdong 519041, China.
3. Department of Immunology and Pathogen Biology, Zhuhai Campus of Zunyi Medical University, Zhuhai Guangdong 519041, China. xiaqiang1973@
4. com.
- Publication Type:Review
- Keywords:
T cell receptor;
T cells;
hepatitis B surface antibody;
hepatitis B vaccine;
immune repertoire;
immune repertoire sequencing;
immune response
- MeSH:
Humans;
Hepatitis B Vaccines/immunology*;
Hepatitis B/immunology*;
Vaccination;
Hepatitis B Antibodies/blood*;
T-Lymphocytes/immunology*;
Receptors, Antigen, T-Cell/immunology*;
Hepatitis B Surface Antigens/immunology*;
T-Lymphocyte Subsets/immunology*
- From:
Journal of Central South University(Medical Sciences)
2024;49(12):1983-1990
- CountryChina
- Language:English
-
Abstract:
Hepatitis B is a global public health concern. Inducing hepatitis B surface antibody (HBsAb) through vaccination is a crucial preventive strategy. However, individuals show varying immune responses to the hepatitis B vaccine. Based on HBsAb levels, individuals can be categorized as high responders, low responders, or non-responders. T cells and their subsets play critical roles in modulating this response, and the composition of the T cell receptor (TCR) repertoire also influences immune responsiveness. Investigating the characteristics of T cells, their subsets, and TCR repertoires in individuals with differential responses post-vaccination may provide theoretical guidance for optimizing vaccine design and immunization strategies.
