RNA-binding proteins regulate osteoarthritis via RNA metabolism regulation.
10.11817/j.issn.1672-7347.2024.240261
- Author:
Jingyue SU
1
,
2
,
3
;
Siyu CHEN
1
;
Shengwu YANG
4
;
Zhenhan DENG
1
,
5
Author Information
1. Graduate School, Guangxi University of Chinese Medicine, Nanning,
2. 18185038937@
3. com.
4. Department of Orthopaedic Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou Zhejiang
5. dengzhenhan@wmu.edu.cn.
- Publication Type:Review
- Keywords:
RNA metabolism;
RNA-binding proteins;
gene expression regulation;
osteoarthritis
- MeSH:
Humans;
Osteoarthritis/genetics*;
RNA-Binding Proteins/genetics*;
RNA/genetics*;
Animals
- From:
Journal of Central South University(Medical Sciences)
2024;49(12):1973-1982
- CountryChina
- Language:English
-
Abstract:
Osteoarthritis (OA) is a common chronic degenerative disease of the skeletal system and muscular system, and its pathogenesis remains unclear, leading to a lack of effective therapeutic strategies. Ribonucleic acid binding proteins (RBP), as key regulators of post-transcriptional processes, can specifically bind to targeted ribonucleic acids (RNA) and modulate their function and fate. By regulating various aspects of RNA metabolism, including transcription, splicing, modification, stabilization, and translation, RBPs influence the onset and progression of OA. Exploring the regulatory mechanisms of RBPs under physiological and pathological conditions, elucidating the role of RBPs in the occurrence and development of OA, and discussing current challenges and future directions in RBPs research, hold significant importance for the treatment of OA by targeting RBPs.
