Research progress in estrogen as an adjunctive therapy for schizophrenia.
10.11817/j.issn.1672-7347.2024.240289
- Author:
Yanyu GE
1
,
2
;
Shungeng ZHANG
3
;
Xinbin GE
4
;
Ranran LI
5
;
Jinguo ZHAI
1
;
Yan GAO
1
,
6
,
7
Author Information
1. School of Mental Health, Jining Medical University, Jining Shandong
2. 1161845783@qq.com.
3. School of Clinical Medicine, Jining Medical University, Jining Shandong
4. Department of General Surgery, Third Bethune Hospital of Jilin University, Changchun
5. Department of Psychiatry, Shandong Mental Health Center, Jinan 250014, China.
6. gaoywl@
7. com.
- Publication Type:Systematic Review
- Keywords:
adjunctive therapy;
estrogen;
gender difference;
reproduction cycle;
schizophrenia
- MeSH:
Humans;
Schizophrenia/drug therapy*;
Estrogens/therapeutic use*;
Antipsychotic Agents/administration & dosage*;
Male;
Female;
Sex Characteristics;
Clinical Trials as Topic;
Estrogen Replacement Therapy
- From:
Journal of Central South University(Medical Sciences)
2024;49(11):1849-1860
- CountryChina
- Language:English
-
Abstract:
Schizophrenia is a chronic psychiatric disorder with complex etiology and diverse clinical manifestations, whose pathogenesis and triggering factors remain incompletely understood. Numerous studies have demonstrated significant gender differences in the age of onset, clinical presentation, disease progression, treatment efficacy, and prognosis among patients with schizophrenia. These differences are largely attributed to variations in sex hormone levels, with estrogen emerging as a key focus of research. Some studies suggest that adjunctive estrogen therapy during schizophrenia treatment not only alleviates symptoms but also reduces the required dosage of antipsychotic medications. A systematic review of research on estrogen as an adjunctive treatment for schizophrenia may provide new perspectives and references for future therapeutic strategies.
