Mechanisms and multimodal treatment of neuropathic pain associated with degenerative cervical spondylosis: Current status and progress.
10.11817/j.issn.1672-7347.2024.240181
- Author:
Jianxiong ZHUANG
1
,
2
;
Yizhang MO
3
;
Zongyuan DENG
1
;
Changxiang LIANG
1
;
Dong YIN
1
,
4
,
5
Author Information
1. Department of Spine Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou
2. zhuangwhu@qq.com.
3. Department of Spine Surgery, Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.
4. tony-inn@
5. com.
- Publication Type:Review
- Keywords:
degenerative cervical spondylosis;
multimodal therapy;
neuroinflammation;
neuropathic pain;
personalized treatment
- MeSH:
Humans;
Spondylosis/therapy*;
Neuralgia/diagnosis*;
Combined Modality Therapy;
Cervical Vertebrae;
Intervertebral Disc Degeneration/complications*;
Physical Therapy Modalities
- From:
Journal of Central South University(Medical Sciences)
2024;49(11):1840-1848
- CountryChina
- Language:English
-
Abstract:
Degenerative cervical spondylosis is a common spinal disorder in the elderly. During its progression, structural changes such as intervertebral disc degeneration, vertebral osteophyte formation, and facet joint degeneration directly impact neural structures, resulting in neuropathic pain. Moreover, the release of inflammatory mediators can further exacerbate pain, and increased neuronal excitability is considered one of the key pathological mechanisms of neuropathic pain. Current diagnostic and assessment methods for neuropathic pain associated with degenerative cervical spondylosis include clinical evaluation, imaging techniques (such as X-ray, computed tomography, and magnetic resonance imaging), and neurophysiological examinations (including electromyography and nerve conduction studies). Treatment options primarily involve pharmacological therapy, physical therapy, and surgical intervention, which have shown promising short-term outcomes. Despite progress made through the combined use of various treatment modalities, their long-term efficacy and safety remain to be further investigated. Personalized and multimodal treatment strategies are essential for improving patients' quality of life. Future research should continue to explore pain mechanisms and develop innovative therapeutic techniques to optimize clinical management.
