A single-center retrospective study of pathogen distribution and antibiotic resistance of bloodstream infections in emergency department.
10.11817/j.issn.1672-7347.2024.240333
- Author:
Yishu TANG
1
,
2
;
Lihua CHEN
3
;
Jie XIAO
1
;
Kun YAN
1
;
Jing QI
1
;
Kefu ZHOU
1
;
Huaizheng LIU
1
,
4
Author Information
1. Department of Emergency, Third Xiangya Hospital, Central South University, Changsha
2. 787221557@qq.com.
3. Department of Laboratory Medicine, Third Xiangya Hospital, Central South University, Changsha 410013, China.
4. lhz3385@csu.edu.cn.
- Publication Type:Journal Article
- Keywords:
bloodstream infection;
drug resistance;
emergency department;
epidemiology;
pathogen
- MeSH:
Retrospective Studies;
Emergency Service, Hospital/statistics & numerical data*;
Drug Resistance, Bacterial;
Anti-Bacterial Agents/therapeutic use*;
Incidence;
Microbial Sensitivity Tests/statistics & numerical data*;
Bacteremia/microbiology*;
Community-Acquired Infections/microbiology*;
Gram-Negative Bacteria/isolation & purification*;
Blood Culture/statistics & numerical data*;
Humans;
Male;
Female;
Adolescent;
Young Adult;
Adult;
Middle Aged;
Aged;
Aged, 80 and over;
China/epidemiology*
- From:
Journal of Central South University(Medical Sciences)
2024;49(11):1799-1807
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:Bloodstream infections in emergency patients have a high incidence, severe disease progression, and rapid deterioration. Early administration of appropriate antimicrobial agents is crucial for improving patient outcomes. This study aims to investigate the incidence, pathogen distribution, and antimicrobial resistance patterns of bloodstream infections in emergency patients, providing a reference for rational antibiotic use in clinical practice.
METHODS:Medical records of patients diagnosed with bloodstream infections in the emergency department of a hospital in Hunan Province between January 2018 and October 2022 were retrospectively collected. Clinical characteristics of bloodstream infection patients were analyzed, and the distribution trends and antimicrobial susceptibility of clinical isolates were examined.
RESULTS:During the study period, 2 215 blood culture samples were submitted from the emergency department, with a positivity rate of 13.27%. After excluding eight cases with missing data or suspected contamination, 286 patients with bloodstream infections were included, with community-acquired infections accounting for the majority (85.66%). The most common primary infection site was the urinary tract (24.48%), followed by respiratory tract infections (20.28%) and biliary and intra-abdominal infections (17.13%). The 30-day mortality rate of bloodstream infections was 16.08%. A total of 286 pathogens were isolated, including 181 (63.29%) Gram-negative bacteria, primarily Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa; 101 (35.31%) Gram-positive bacteria, mainly Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus pneumoniae; and only 4 (1.40%) fungal isolates. Antimicrobial susceptibility testing showed that the key Enterobacteriaceae strains exhibited resistance rates of 2.4% to carbapenems, 16.3% to piperacillin sodium and tazobactam sodium, and 15.3% to ceftazidime, with no detected resistance to tigecycline or polymyxins. The main non-fermentative bacteria showed resistance rates of 29.6% to piperacillin sodium and tazobactam sodium, 13.3% to cefoperazone sodium and sulbactam sodium, and 27.1% to quinolones. Among Gram-negative bacteria, multidrug-resistant strains accounted for 40.9% (74/181), with carbapenem-resistant Escherichia coli and Klebsiella pneumoniae detected in 5.4% (5/92) and 13.6% (6/44) of cases, respectively. No carbapenem-resistant Pseudomonas aeruginosa was identified. Among Gram-positive bacteria, resistance rates to penicillin G, rifampicin, and cefoxitin were 74.7%, 4.2%, and 50%, respectively, with only 3 cases of resistant to glycopeptide antibiotics.
CONCLUSIONS:Bloodstream infections in emergency patients are predominantly community-acquired, with Gram-negative bacteria being the most common pathogens. The isolated pathogens exhibited relatively low resistance rates to commonly used clinical antibiotics.
