Mechanism and Application of Chinese Herb Medicine in Treatment of Peripheral Nerve Injury.
10.1007/s11655-024-4004-1
- Author:
Yu-Qing CHEN
1
;
Yan-Xian ZHANG
1
;
Xu ZHANG
2
;
Yong-Mei LYU
3
;
Zeng-Li MIAO
2
;
Xiao-Yu LIU
1
;
Xu-Chu DUAN
4
Author Information
1. School of Life Science, Nantong Laboratory of Development and Diseases, Affiliated Hospital of Nantong University, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, 226019, China.
2. Clinical Medical Research Center, Department of Neurosurgery, Wuxi No. 2 Peolpe's Hospital, Jiangnan University Medical Center, Affiliated Wuxi Clinical College of Nantong University, Wuxi, Jiangsu Province, 214002, China.
3. School of Marine and Bioengineering, Yancheng Institute of Technology, Yancheng, Jiangsu Province, 224007, China.
4. School of Life Science, Nantong Laboratory of Development and Diseases, Affiliated Hospital of Nantong University, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, 226019, China. dxd2002sk@ntu.edu.cn.
- Publication Type:Review
- Keywords:
Chinese herb medicine;
mechanism;
natural product;
peripheral nerve injury;
peripheral nerve regeneration
- MeSH:
Drugs, Chinese Herbal/pharmacology*;
Humans;
Peripheral Nerve Injuries/drug therapy*;
Animals;
Nerve Regeneration/drug effects*;
Medicine, Chinese Traditional
- From:
Chinese journal of integrative medicine
2025;31(3):270-280
- CountryChina
- Language:English
-
Abstract:
Peripheral nerve injury (PNI) encompasses damage to nerves located outside the central nervous system, adversely affecting both motor and sensory functions. Although peripheral nerves possess an intrinsic capacity for self-repair, severe injuries frequently result in significant tissue loss and erroneous axonal junctions, thereby impeding complete recovery and potentially causing neuropathic pain. Various therapeutic strategies, including surgical interventions, biomaterials, and pharmacological agents, have been developed to enhance nerve repair processes. While preclinical studies in animal models have demonstrated the efficacy of certain pharmacological agents in promoting nerve regeneration and mitigating inflammation, only a limited number of these agents have been translated into clinical practice to expedite nerve regeneration. Chinese herb medicine (CHM) possesses a longstanding history in the treatment of various ailments and demonstrates potential efficacy in addressing PNI through its distinctive, cost-effective, and multifaceted methodologies. This review critically examines the advancements in the application of CHM for PNI treatment and nerve regeneration. In particular, we have summarized the most commonly employed and rigorously investigated CHM prescriptions, individual herbs, and natural products, elucidating their respective functions and underlying mechanisms in the context of PNI treatment. Furthermore, we have deliberated on the prospective development of CHM in both clinical practice and fundamental research.
