Research Progress of Chinese Medicine Monomers in Treatment of Cholangiocarcinoma.
10.1007/s11655-024-4203-9
- Author:
Xiang WANG
1
;
Xiao-Qing WANG
2
;
Kai LUO
2
;
He BAI
2
;
Jia-Lin QI
2
;
Gui-Xin ZHANG
3
,
4
Author Information
1. Department of General Surgery, the Second Hospital of Dalian Medical University, Dalian, Liaoning Province, 116027, China.
2. Clinical Laboratory of Integrative Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, 116021, China.
3. Department of General Surgery, the Second Hospital of Dalian Medical University, Dalian, Liaoning Province, 116027, China. zhangguixin2024@
4. com.
- Publication Type:Review
- Keywords:
Chinese medicine;
antitumor;
cholangiocarcinoma;
molecular mechanisms;
monomers;
review;
signaling pathways
- MeSH:
Cholangiocarcinoma/drug therapy*;
Humans;
Drugs, Chinese Herbal/pharmacology*;
Bile Duct Neoplasms/drug therapy*;
Medicine, Chinese Traditional;
Animals;
Signal Transduction/drug effects*
- From:
Chinese journal of integrative medicine
2025;31(2):170-182
- CountryChina
- Language:English
-
Abstract:
Cholangiocarcinoma (CCA) is a malignant tumor originating from cholangiocytes. However, it remains unclear about the pathogenesis of this carcinoma, which may be related to multiple factors. Currently, CCA is mainly treated by surgery, chemotherapy, and radiotherapy. Among them, surgery is the only potentially curative option for CCA. Nevertheless, the high malignancy and asymptomatic nature of CCA may lead to poor treatment outcomes. It has been demonstrated that Chinese medicine (CM) plays a significant role in various antitumor applications. Meanwhile, CM exhibits fewer side effects and high availability. Moreover, the in vitro application of CM monomers has been explored in many domestic and foreign studies. This article mainly reviews the signaling pathways and molecular mechanisms of CM monomers in the treatment of CCA in recent years. These findings are expected to provide new insights into the treatment of CCA.
