Pharmacological Mechanism of Chinese Medicine in Systemic Lupus Erythematosus: A Narrative Review.
10.1007/s11655-024-3762-0
- Author:
Bo-Yu ZHU
1
;
Zhi-Chao LIU
1
;
Zhen-Xi ZHAO
1
;
Hui-Ping HUANG
1
;
Na ZHANG
1
;
Jia XIA
1
;
Wei-Wei CHEN
2
Author Information
1. Department of Rheumatology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, China.
2. Department of Rheumatology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, China. chenweiwei@shutcm.edu.cn.
- Publication Type:Review
- Keywords:
Chinese medicine;
natural extracts;
review;
systemic lupus erythematosus;
treatment
- MeSH:
Lupus Erythematosus, Systemic/immunology*;
Humans;
Medicine, Chinese Traditional;
Drugs, Chinese Herbal/pharmacology*;
Animals
- From:
Chinese journal of integrative medicine
2025;31(2):157-169
- CountryChina
- Language:English
-
Abstract:
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder affecting multiple systems, characterized by the development of harmful autoantibodies and immune complexes that lead to damage in organs and tissues. Chinese medicine (CM) plays a role in mitigating complications, enhancing treatment effectiveness, and reducing toxicity of concurrent medications, and ensuring a safe pregnancy. However, CM mainly solves the disease comprehensively through multi-target and multi-channel regulation process, therefore, its treatment mechanism is often complicated, involving many molecular links. This review introduces the research progress of pathogenesis of SLE from the aspects of genetics, epigenetics, innate immunity and acquired immunity, and then discusses the molecular mechanism and target of single Chinese herbal medicine and prescription that are commonly used and effective in clinic to treat SLE.
