Exploring Mechanism of Electroacupuncture in Modulating Neuroinflammation Based on Intestinal Flora and Its Metabolites.
10.1007/s11655-024-3766-9
- Author:
Hai-Min YE
1
;
Zhuo-Yan LI
2
;
Peng ZHANG
3
;
Zhen KANG
3
;
De-Sheng ZHOU
4
Author Information
1. School of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, 410208, China.
2. Neurology Department, The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, 410005, China.
3. Acupuncture and Moxibustion Massage Rehabilitation Department, The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, 410005, China.
4. Neurology Department, The First Hospital of Hunan University of Chinese Medicine, Changsha, 410011, China. zds1101@foxmail.com.
- Publication Type:Review
- Keywords:
electroacupuncture;
intestinal flora;
metabolites of intestinal flora;
nervous system disease;
neuroinflammation;
review
- MeSH:
Humans;
Gastrointestinal Microbiome;
Electroacupuncture;
Neuroinflammatory Diseases/metabolism*;
Animals
- From:
Chinese journal of integrative medicine
2025;31(2):183-192
- CountryChina
- Language:English
-
Abstract:
Neuroinflammatory responses play an important role in the pathogenesis of various diseases, particularly those affecting the central nervous system. Inhibition of neuroinflammation is a crucial therapeutic strategy for the management of central nervous system disorders. The intestinal microbial-gut-brain axis serves as a key regulatory pathway that modulates neuroinflammatory processes. Intestinal flora metabolites such as short-chain fatty acids, indoles and their derivatives, lipopolysaccharides, trimethylamine oxide, and secondary bile acids exert direct or indirect effects on neuroinflammation. Studies have shown that electroacupuncture (EA) modulates the composition of the intestinal microbiota and its metabolites, while also suppressing neuroinflammation by targeting the TLR4/NF- κ B, NLRP3/caspase-1, and microglial cell M2-type transformation pathways. This review discusses the mechanisms by which EA regulates neuroinflammation via intestinal microbiota and its metabolites, providing information and a foundation for further investigation of the precise therapeutic mechanisms of EA in neurological disorders.
