Revolutionizing Gastric Cancer Prevention: Novel Insights on Gastric Mucosal Inflammation-Cancer Transformation and Chinese Medicine.
10.1007/s11655-024-3806-5
- Author:
Lin LIU
1
;
Xiao-Hui FAN
2
;
Xu-Dong TANG
3
Author Information
1. Institute of Digestive Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
2. School of Pharmacy, Zhejiang University, Hangzhou, 310058, China.
3. Institute of Digestive Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China. txdly@sina.com.
- Publication Type:Review
- Keywords:
gastric cancer;
gastric mucosal inflammation-cancer transformation;
gastric precancerous lesions;
modernization of Chinese medicine;
review;
spasmolytic polypeptide-expressing metaplasia
- MeSH:
Stomach Neoplasms/pathology*;
Humans;
Cell Transformation, Neoplastic/pathology*;
Gastric Mucosa/pathology*;
Medicine, Chinese Traditional;
Inflammation/pathology*;
Animals
- From:
Chinese journal of integrative medicine
2025;31(10):942-952
- CountryChina
- Language:English
-
Abstract:
The progression from gastric mucosal inflammation to cancer signifies a pivotal event in the trajectory of gastric cancer (GC) development. Chinese medicine (CM) exhibits unique advantages and holds significant promise in inhibiting carcinogenesis of the gastric mucosa. This review intricately examines the critical pathological events during the transition from gastric mucosal inflammation-cancer transformation (GMICT), with a particular focus on pathological evolution mechanisms of spasmolytic polypeptide-expressing metaplasia (SPEM). Moreover, it investigates the pioneering applications and advancements of CM in intervening within the medical research domain of precancerous transformations leading to GC. Furthermore, the analysis extends to major shortcomings and challenges confronted by current research in gastric precancerous lesions, and innovative studies related to CM are presented. We offer a highly succinct yet optimistic outlook on future developmental trends. This paper endeavors to foster a profound understanding of forefront dynamics in GMICT research and scientific implications of modernizing CM. It also introduces a novel perspective for establishing a collaborative secondary prevention system for GC that integrates both Western and Chinese medicines.
