Determination of Volatile Organic Compounds in Medical Molecular Sieve Oxygen Concentrators by Thermal Desorption-Gas Chromatography-Mass Spectrometry.
10.12455/j.issn.1671-7104.250134
- Author:
Danmei ZHAO
1
;
Bin XUE
2
;
Congkai WEI
1
;
Haihua KANG
1
;
Yuanli HUANG
1
;
Linnan KE
1
Author Information
1. National Institutes for Food and Drug Control, Beijing,
2. Center for Informations, NMPA, Beijing,
- Publication Type:Journal Article
- Keywords:
medical molecular sieve oxygen concentrator;
thermal desorption-gas chromatography-mass spectrometry (TD-GC-MS);
volatile organic compounds (VOCs)
- MeSH:
Volatile Organic Compounds/analysis*;
Gas Chromatography-Mass Spectrometry/methods*;
Oxygen
- From:
Chinese Journal of Medical Instrumentation
2025;49(5):585-590
- CountryChina
- Language:Chinese
-
Abstract:
A method for determining volatile organic compounds (VOCs) emitted from medical molecular sieve oxygen concentrators was developed using thermal desorption-gas chromatography-mass spectrometry (TD-GC-MS). The oxygen concentrator gas was sampled at a flow rate of 0.5 L/min through a branched sampling system onto Tenax GR/carbopack B adsorption tubes. The adsorbed compounds were desorbed and introduced using a programmed temperature vaporization inlet system, followed by chromatographic separation on an SH-I-624Sil MS column. Four VOCs (BHT-Q, PTBP, BHT-quinol, and EHB) were detected in the medical oxygen concentrator using this method. Calibration curves for these compounds exhibited excellent linearity ( R 2>0.99) within the range of 3~100 ng. With a sampling volume of 20 L, the detection limit of the four VOCs ranged from 0.003 9 to 0.022 2 μg/m 3. Spike recovery rates for the four VOCs were between 95% and 115%, with relative standard deviations (RSDs) below 5% ( n=6). The method is simple, rapid, highly sensitive, and accurate, making it suitable for VOCs detection in medical molecular sieve oxygen concentrators.
