Current Research Status of Biomedical Hydrogel and Challenges and Opportunities in Clinical Translation.
10.12455/j.issn.1671-7104.250081
- Author:
Huan LIAN
1
;
Li LIU
1
;
Linnan KE
1
Author Information
1. General Office of State Key Laboratory of Drug Regulatory Science, Department of Medical Devices, National Institutes for Food and Drug Control, Beijing,
- Publication Type:Journal Article
- Keywords:
4D printing;
clinical translation;
hydrogel;
intelligent biomaterials;
regulatory science
- MeSH:
Hydrogels;
Tissue Engineering;
Translational Research, Biomedical;
Biocompatible Materials;
Humans;
Drug Delivery Systems
- From:
Chinese Journal of Medical Instrumentation
2025;49(5):520-526
- CountryChina
- Language:Chinese
-
Abstract:
As representatives of the third generation of biomedical materials, hydrogels exhibit revolutionary potential in tissue engineering, precision drug delivery, and smart medical devices due to their ability to construct bionic microenvironments. However, the clinical translation of hydrogels is still limited by multidimensional challenges, including biocompatibility, scalable production, and regulatory complexity. This paper systematically reviews the design innovations, functionalization strategies, and translational bottlenecks of hydrogel materials, integrates the latest technological trends, such as 4D printing and AI-driven design, and proposes a collaborative optimization pathway encompassing materials, technology, clinical applications, and policy. By introducing local Chinese innovation cases and monitoring scientific advancements, this study offers solutions that possess both academic significance and practical guidance for the clinical translation of hydrogels.
