Study on Performance of Nebulizer for Pressurized Intraperitoneal Aerosol Chemotherapy.
10.12455/j.issn.1671-7104.240696
- Author:
Lanfeng ZHANG
1
;
Guangjun GUO
1
;
Guibing HOU
1
Author Information
1. Ssejoy Medical Technology (Tianjin) Co., Ltd., Tianjin,
- Publication Type:Journal Article
- Keywords:
aerosolization;
median droplet diameter (D50);
peritoneal metastasis (PM);
pressurized intraperitoneal aerosol chemotherapy (PIPAC);
spray angle
- MeSH:
Nebulizers and Vaporizers;
Aerosols;
Particle Size;
Pressure;
Drug Delivery Systems
- From:
Chinese Journal of Medical Instrumentation
2025;49(3):330-335
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:The study investigates the performance parameters of a nebulizer for pressurized intraperitoneal aerosol chemotherapy (PIPAC).
METHODS:Laser diffraction spectroscopy was used to measure the median droplet diameter ( D 50) and spray angle during the steady-state aerosol phase.
RESULTS:The minimum droplet diameter of aerosol was achieved when using a nozzle of 0.2 mm diameter and 0.07 mm thickness. The nebulizer could not produce steady-state aerosol when the liquid flow rate was less than or equal to 0.3 mL/s. When the liquid flow rate was greater than or equal to 0.5 mL/s, as the working pressure increased, the median particle size gradually decreased and the spray angle gradually increased. When the pressure is greater than or equal to 200 psi（1 psi=6 894.76 Pa）, as the liquid flow rate increased, the spray angle gradually increased. At a flow rate of 0.7 mL/s and working pressure of 300 psi, the median droplet diameter of aerosol D 50 was 16 μm with a spray angle up to 89.2°.
CONCLUSION:As a novel intraperitoneal drug delivery technology, PIPAC requires further research focusing on reducing droplet size, expanding drug distribution, improving tissue permeability, and increasing drug concentration.
