Expression of lumican protein in serum of patients with rheumatoid arthritis and its correlation with disease and immune activities
10.19723/j.issn.1671-167X.2025.05.015
- VernacularTitle:Lumican蛋白在类风湿关节炎患者血清中的表达及其与疾病和免疫活动的相关性
- Author:
Ju YANG
1
;
Jing XU
;
Juhua DAI
;
Lianjie SHI
Author Information
1. 遂宁市中心医院老年医学科,四川遂宁 629000;川北医学院临床医学系,四川南充 637000
- Publication Type:Journal Article
- Keywords:
Lumican;
Rheumatoid arthritis;
Rheumatoid factor;
Anti-citrullinated protein antibodies
- From:
Journal of Peking University(Health Sciences)
2025;57(5):911-918
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the serum level of lumican(LUM)and its clinical correlation with disease and immune activities in patients with rheumatoid arthritis(RA).Methods:The serum LUM levels in both RA patients and health controls(HCs)were detected by enzyme-linked immunosor-bent assay(ELISA).The clinical and laboratory data of the patients were collected.The LUM levels in the patients with different clinical features were analyzed.The correlation between the clinical data,labo-ratory parameters,and serum LUM levels were also analyzed.Independent samples t test,Spearman cor-relation were used for statistical analysis.Analysis of variance and Kruskal-Wallis test,the least signifi-cant difference(LSD)-t test and Bonferroni correction were used for statistical analysis.The Pearson Chi-square test was used for comparison of the rates between the groups.Statistical significance was set at P＜0.05.Results:The levels of LUM were elevated in the RA patients than in the HCs(P＜0.000 1).Serum LUM levels were correlated with the erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),rheumatoid factor(RF),immunoglobulin A(IgA),titers of platelet(PLT)and 28-joint disease activity score(DAS28,all P＜0.05).Next,we compared the serum LUM levels in the RA patients with different characteristics,and no difference was found in serum LUM levels between early-RA and RA,the same to RA with different gender(P＞0.05).The levels of serum LUM were elevated in the RF positive patients(P＜0.000 1),and in the RF and anti-CCP positive patients(P＜0.05)than in the RA patients with negative RF whether the anti-CCP was positive.In addition,no differences were found between the RA patients with negative RF whether the anti-CCP was positive(P＞0.05).All the levels of serum LUM were elevated in the RA patients with different CRP or ESR than in the HCs(P＜0.05),and the serum LUM levels in the RA patients with elevated ESR and CRP were significantly elevated in those with normal ESR and CRP(P＜0.05).Additionally,the results demonstrated that serum LUM levels were positively associated with RA disease activity,and they were declined in RA sustained remis-sion than those in middle or high disease activity(P＜0.05).Furthermore,no difference was found be-tween the RA patients in remission and HCs(P＞0.05).No differences were found in the RA patients with and without complications including interstitial pneumonia disease,Sj?gren's syndrome,thyroid gland diseases and osteoporosis(P＞0.05).The LUM positivity rates were significantly elevated in the RF posi-tive patients than the RF negative patients in RA(P＜0.05).Conclusion:LUM,a cyclocitrullinated pro-tein,might be a promising biomarker which could reflect both disease activity and immune activity in RA.
