Microneedle combined with photodynamic therapy in the treatment of oral leukopla-kia
10.19723/j.issn.1671-167X.2025.01.014
- VernacularTitle:细针扣刺预处理联合光动力疗法治疗口腔白斑
- Author:
Ying HAN
1
;
Pu ZHAO
1
;
Hongwei LIU
1
Author Information
1. 北京大学口腔医学院·口腔医院口腔黏膜科,国家口腔医学中心,国家口腔疾病临床医学研究中心,口腔生物材料和数字诊疗装备国家工程研究中心,国家药品监督管理局口腔材料重点实验室,北京 100081
- Publication Type:Journal Article
- Keywords:
Oral leukoplakia;
Photodynamic therapy;
Microneedle pretreatment
- From:
Journal of Peking University(Health Sciences)
2025;57(1):91-96
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore whether microneedle pretreatment can significantly improve the effi-cacy and safety of 5-aminolevulinic acid(ALA)-photodynamic therapy(PDT)in the treatment of oral leukoplakia.Methods:A non-randomized controlled clinical trial was conducted.Patients with clinical and pathological diagnosis of oral leukoplakia in the Department of Oral Mucosa,Peking University School and Hospital of Stomatology were divided into experimental group and control group.The control group was treated with conventional ALA-PDT,and the experimental group was pretreated with micro-needle buckling under superficial anesthesia with lidocaine before conventional ALA-PDT.The clinical mani-festations of the two groups were recorded,the lesion area was measured,the clinical efficacy was evalua-ted,the number of treatment sessions and treatment unit duration were analyzed,and the pain after treat-ment was evaluated by visual analogue scale.The above data of the two groups were statistically ana-lyzed.Results:A total of 11 patients were included in the experimental group and 19 patients were in-cluded in the control group.The complete remission rate of the experimental group and the control group was 45.5％and 36.8％,the partial remission rate was 54.5％and 57.9％,and the no remission rate was 0％and 5％,respectively.There was no significant difference in the treatment effect between the two groups.Meanwhile,the treatment unit duration of the experimental group and the control group were(9.05±5.74)min/cm and(21.38±15.44)min/cm2,respectively,and the number of treatment ses-sions were(2.36±0.67)times and(3.58±1.57)times,respectively.These differences between the two groups were statistically significant(t=-3.125,P＜0.05;t=-2.932,P＜0.05).Similarly,multiple linear regression analysis with 7 factors including age,dysplastic pathology,lesion classification,etc.,also confirmed that pretreatment could significantly shorten the treatment unit duration(P＜0.05).In addition,there was no significant difference in pain score(visual analogue scale)between the two groups after treatment,and the microneedle puncture pretreatment did not increase the adverse reactions of ALA-PDT treatment.Conclusion:Microneedle pretreatment followed by conventional ALA-PDT shows a good clinical effect on oral leukoplakia,which can significantly shorten the clinical treatment time,re-duce the number of visits,and save medical costs.
