Impact of type 2 diabetes mellitus on the prognosis of patients with oral squamous cell carcinoma
10.19723/j.issn.1671-167X.2024.06.023
- VernacularTitle:2型糖尿病对口腔鳞状细胞癌患者预后的影响
- Author:
Yaqing MAO
1
;
Zhen CHEN
;
Yao YU
;
Wenbo ZHANG
;
Yang LIU
;
Xin PENG
Author Information
1. 北京大学口腔医学院·口腔医院口腔颌面外科,北京 100081
- Publication Type:Journal Article
- Keywords:
Oral squamous cell carcinoma;
Diabetes mellitus;
Prognosis;
Propensity score matching
- From:
Journal of Peking University(Health Sciences)
2024;56(6):1089-1096
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the influence of type 2 diabetes mellitus(DM)on the prognosis of oral squamous cell carcinoma(OSCC)patients with surgical treatment.Methods:The clinical data of 309 patients,who were diagnosed with OSCC and admitted to the same ward of Peking University Hospi-tal of Stomatology from January 2014 to December 2017 were retrospectively reviewed,of whom,104 were classified into DM group and 205 into non-DM group.The basic clinical data and follow-up results of the patients were analyzed and compared.Propensity score matching(PSM)was used to reduce con-founding bias between the DM group and the non-DM group.Kaplan-Meier was used to calculate the sur-vival rate of the two groups.Proportional hazards model was used to analyze the independent prognostic factors.The effect of glucose level on survival was analyzed.Results:After PSM,77 patients in each group were matched and the variables were balanced.There were statistically significant differences in postoperative oral dysplasia and local recurrence between the two groups(P＜0.05).There was no sig-nificant difference in survival analysis between the two groups,but the survival rate of the DM group had the tendency to be lower than that of the non-DM group after matching.Univariate analysis and multiva-riate analysis both revealed that the tumor stage was an independent factor influencing the overall survival rate and tumor-specific survival rate of the OSCC patients(P＜0.05),while diabetes had no significant influence on the survival of the OSCC patients(P＞0.05).Multivariate analysis showed that tumor stage,triglyceride level,preoperative mean capillary fasting blood glucose,postoperative mean postpran-dial blood glucose were indepen-dent prognostic factors for overall survival in the DM group.Tumor stage and mean postoperative postprandial blood glucose were independent prognostic factors for tumor-specific survival in the DM group.The risk of postoperative complications and distant metastasis in the DM group with poor glycemic control was higher than that in the good glycemic controls.Conclusion:There is no significant difference in overall survival and tumor-specific survival of the patients with or without DM.However,the possibility of mucosal dysplasia or local recurrence in the DM group is higher than that in the non-DM group.The tumor stage,triglyceride level and glycemic control of the patients with DM may affect their prognosis.
