Analysis of characteristics related to the disease activity of systemic lupus erythemato-sus and construction of an evaluation model
10.19723/j.issn.1671-167X.2024.06.011
- VernacularTitle:系统性红斑狼疮疾病活动度相关特征分析及评估模型的构建
- Author:
Hongyan WANG
1
;
Xinming LI
;
Kechi FANG
;
Huaqun ZHU
;
Rulin JIA
;
Jing WANG
Author Information
1. 北京大学人民医院风湿免疫科,北京 100044
- Publication Type:Journal Article
- Keywords:
Systemic lupus erythematosus;
Clinical stratification;
Disease activity;
Clinical indicators
- From:
Journal of Peking University(Health Sciences)
2024;56(6):1017-1022
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To stratify systemic lupus erythematosus(SLE)patients clinically,to analyze the clinical characteristics of patients with and without disease activity,and to explore the application va-lue of key clinical indicators in assessing disease activity,as well as to construct an evaluation model.Methods:A retrospective analysis was conducted on clinical data of the SLE patients diagnosed at Peking University People's Hospital from May 1995 to April 2014.Demographic information,clinical manifesta-tions,laboratory tests,and antibody detection results were collected.The patients were divided into ac-tive and inactive groups based on systemic lupus erythematosus disease activity index 2000(SLEDAI-2000)scores.t-tests,Mann-Whitney U tests,andx2tests were used to compare the differences between the groups.Spearman correlation analysis was used to evaluate the relevant clinical indicators associated with SLE activity in the active disease group.Based on the results of statistical analysis,a Logistic re-gression model was constructed,and the performance of the model was evaluated.Results:No significant differences were found in demographic characteristics between the two groups.In the active disease group,positive rates of antinuclear antibodies(ANA)and anti-double-stranded DNA antibodies(anti-dsDNA)were increased;white blood cell count(WBC),red blood cell count(RBC),hemoglobin(HGB),lymphocytes(LY),total protein(TP),albumin(ALB),and complement 3(C3)levels were significantly decreased;while immunoglobulin A and G levels were markedly elevated.The correlation analysis results showed that hemoglobin,albumin,C3,and complement 4(C4)had higher correlation indices compared with other clinical indicators.Among these,C3 exhibited a certain negative correlation with disease activity.The Logistic regression model based on 12 significantly different indicators(P＜0.05)achieved an accuracy of 91.4％,sensitivity of 94.4％,specificity of 81.0％,and the area under curve(AUC)of the receiver operating characteristic(ROC)was 0.944.Conclusion:This study com-prehensively evaluated a range of clinical indicators related to SLE disease activity,providing a thorough understanding of both laboratory and clinical markers.The Logistic regression model,which was primari-ly constructed using laboratory test indicators,such as inflammatory markers,immune response parame-ters,and organ involvement metrics,demonstrated a high degree of accuracy in assessing the disease ac-tivity in SLE patients.Consequently,this model might provide a new basis for the diagnosis and treatment of SLE patients,offering significant clinical diagnostic value.
