Diagnostic significance of serum chemokine CXCL-10 and Krebs von den lungen-6 level in patients with rheumatoid arthritis associated interstitial lung disease
10.19723/j.issn.1671-167X.2024.06.003
- VernacularTitle:血清趋化因子CXCL-10和涎液化糖链抗原6水平在类风湿关节炎合并肺间质病变患者中的诊断和病情评估价值
- Author:
Rui YAN
1
;
Dan KE
;
Yan ZHANG
;
Li LI
;
Huanran SU
;
Wei CHEN
;
Mingxia SUN
;
Xiaomin LIU
;
Liang LUO
Author Information
1. 北京市顺义区医院风湿免疫科,北京 101300
- Publication Type:Journal Article
- Keywords:
Chemokine;
CXC motif chemokine 10(CXCL-10);
Rheumatoid arthritis;
Interstitial lung disease
- From:
Journal of Peking University(Health Sciences)
2024;56(6):956-962
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect the serum level of chemokine CXC motif chemokine 10(CXCL-10)and Krebs von den lungen-6(KL-6)in patients with rheumatoid arthritis associated interstitial lung dis-ease(RA-ILD),and to analyze their correlation with RA-ILD,as well as the significance in RA-ILD.Methods:A total of 169 RA patients were enrolled in the study.According to imaging findings of with and without ILD in high-resolution computed tomography scans of chest,the subjects were divided into RA-ILD group and RA-non-ILD group.According to the inclusion and exclusion criteria,80 patients in each of the two groups were finally selected.Two groups were matched according to the 1:1 ratio using propensity score matching(PSM).The serum CXCL-10 and KL-6 levels were detected by enzyme-linked immunosorbent assay.The clinical features,laboratory data and medications between the two groups were compared after PSM and the correlation between serum levels and clinical parameters were analyzed.Bi-nary Logistic regression was used to analyze the risk factors of ILD in the RA patients,and the predictive value of CXCL-10 and KL-6 in RA-ILD was evaluated.Results:In this study,49 patients with RA-ILD and 49 patients with RA-non-ILD were selected by PSM.The levels of CXCL-10 and KL-6 in the RA-ILD group[64.36(34.01,110.18)ng/L,360.70(236.35,715.05)U/mL]were significantly higher than those in the RA-non-ILD group[29.80(16.89,40.55)ng/L,210.69(159.98,255.50)U/mL](all P＜0.001).The results of correlation analysis showed that the level of serum CXCL-10 was positively correlated with the Warrick score on chest CT(r=0.378,P=0.007)and negatively correlated with the percentage of forced vital capacity to the predicted value(FVC％,r=-0.338,P=0.018).And the level of KL-6 was positively correlated with rheumatoid factor(RF,r=0.296,P=0.039)and nega-tively correlated with FVC％(r=-0.436,P=0.002)and the percentage of diffusion capacity for car-bon monoxide to the predicted value(DLCO％,r=-0.426,P=0.002).Both univariate and multiva-riate Logistic regression analysis showed that CXCL-10 and KL-6 were positively correlated with ILD,the values of OR were 1.035 and 1.023 in CXCL-10 and those were 1.004 and 1.005 in KL-6 respectively(P＜0.05).The ROC curves were plotted with CXCL-10 and KL-6.The area under the curve(AUC)was 0.770 and 0.752 respectively.The AUC of combined detection increased to 0.800.Conclusion:Serum levels of CXCL-10 and KL-6 are significantly elevated in patients with RA-ILD and correlated with the severity of ILD.The combined estimate of them helps to improve the effectiveness of diagnosis.
