Influences of radiographic silicosis and drug supervisor on the development of multi drug resistant-tuberculosis in West Java, Indonesia.

Leli Hesti INDRIYATI; Masamitsu EITOKU; Naw Awn J-P; Miki NISHIMORI; Norihiko HAMADA; Neni SAWITRI; Narufumi SUGANUMA

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Influences of radiographic silicosis and drug supervisor on the development of multi drug resistant-tuberculosis in West Java, Indonesia.

Author: Leli Hesti INDRIYATI ¹ ; Masamitsu EITOKU ¹ ; Naw Awn J-P ¹ ; Miki NISHIMORI ² ; Norihiko HAMADA ² ; Neni SAWITRI ³ ; Narufumi SUGANUMA ¹
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1. Department of Environmental Medicine, Kochi Medical School, Kochi University.
2. Department of Diagnostic and Interventional Radiology, Kochi Medical School, Kochi University.
3. Department of Pulmonology, RS Paru Dr.M.Goenawan Partowidigdo (RSPG).
Publication Type:Journal Article
Keywords: DOT; Indonesia; MDR-TB; Silico-tuberculosis; Silicosis; Tuberculosis
MeSH: Indonesia/epidemiology*; Humans; Silicosis/diagnostic imaging*; Male; Tuberculosis, Multidrug-Resistant/etiology*; Middle Aged; Adult; Female; Prevalence; Risk Factors; Aged; Antitubercular Agents/therapeutic use*
From:Environmental Health and Preventive Medicine 2025;30():20-20
CountryJapan
Language:English
Abstract: BACKGROUND:Indonesia is among countries with a high incidence of multi drug-resistant tuberculosis (MDR-TB) globally. In this study, we aim to determine the prevalence of silico-tuberculosis among TB patients and to investigate the association of radiographic silicosis and the role of drug supervisor as well as other socio-clinical factors, in the development of MDR-TB in Indonesia.
METHODS:A hospital-based study in West Java among 148 MDR-TB patients (case) and 164 drug-sensitive/DS-TB patients (control) was conducted. Chest x-rays were evaluated by two radiologists and one NIOSH B reader according to the ILO Classification. Face-to-face interviews were conducted using structured questionnaires to collect patients' information, including the task of drug supervisor.
RESULTS:Findings indicate that supportive drug supervisor reduces the risk of developing MDR-TB, but silicosis showed no significant association. Nevertheless, in this study we found that 17 cases (5.4%) had silico-tuberculosis mostly exhibited as ILO profusion 3; predominated by q shape, 52.9% with large opacities and dominated by size A. Other factors significantly associated with the risk of developing MDR-TB were marital status, low income, longer traveling time to hospital, unsuccessful previous treatment and suffering drug side effects.
CONCLUSION:This study reveals that one of preventive healthcare strategy to protect TB patients from developing MDR-TB is supportive drug supervisor. While, the development of MDR-TB was not significantly influenced by silicosis; however, there is a notable prevalence of silicosis as determined by chest radiography, highlighting the critical need for dust control, occupational hygiene, and health screening for high-risk populations.