Tonifying kidney and activating blood therapy for the treatment of diabetic erectile dysfunction:A systematic review and meta-analysis
10.13263/j.cnki.nja.2025.09.010
- VernacularTitle:补肾活血法治疗糖尿病性勃起功能障碍的系统评价与meta分析
- Author:
Mao-ke CHEN
1
;
Ke-cheng LI
1
;
Jun-long FENG
1
;
Xiang-fa LIN
1
;
Wen-xuan DONG
1
;
Zi-xiang GAO
1
;
Hua-nan ZHANG
1
;
Hui CHEN
1
;
Ji-sheng WANG
1
;
Bin WANG
1
Author Information
1. 北京中医药大学东直门医院男科,北京 100700
- Publication Type:Journal Article
- Keywords:
Tonifying kidney and activating blood therapy;
diabetic mellitus erectile dysfunction;
meta-analysis
- From:
National Journal of Andrology
2025;31(9):832-840
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically evaluate the clinical efficacy and safety of Tonifying kidney and activating blood thera-py for the treatment of diabetic mellitus erectile dysfunction.Methods:China National Knowledge Infrastructure(CNKI),Wanfang Data,VIP,Chinese Biomedical Database(CBM),PubMed,Cochrane Library,Embase and Web of Science were searched from incep-tion until October 20th of 2024,for randomized controlled trials of Tonifying kidney and activating blood therapy for the treatment of dia-betic erectile dysfunction.Literature screening,quality evaluation,and data extraction were carried out in accordance with relevant standards.The software of RevMan5.4 was used for the analysis of publication bias.And meta-analysis was conducted to assess the im-pact of this therapy on IIEF-5,total effective rate,adverse reactions.The evidence levels according to the analysis results were evalua-ted.Results:Totally 19 RCTs were included,involving 1 612 patients.The result of meta-analysis indicated that Tonifying kidney and activating blood therapy had advantages on the improvement of IIEF-5 scores(MD=3.59,95％CI[2.14,5.03],P＜0.01),total effective rate(OR=4.30,95％CI[3.29,5.32],P＜0.000 01).However,there was no statistically significant difference in the inci-dence of adverse reactions(OR=0.98,95％CI[0.48,2.01],P=0.96)between the two groups.Conclusions:Tonifying kidney and activating blood therapy can improve the clinical efficacy and IIEF-5 score for the patients with diabetic erectile dysfunction.But considering the limited quantity of included studies,more high-quality studies still be needed to validate the therapeutic effect.
